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首页> 外文期刊>FEMS Yeast Research >Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae.
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Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae.

机译：酿酒酵母重组蛋白分泌的代谢工程。

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The yeast Saccharomyces cerevisiae is a widely used cell factory for the production of fuels and chemicals, and it is also provides a platform for the production of many heterologous proteins of medical or industrial interest. Therefore, many studies have focused on metabolic engineering S.[NON-BREAKING SPACE]cerevisiae to improve the recombinant protein production, and with the development of systems biology, it is interesting to see how this approach can be applied both to gain further insight into protein production and secretion and to further engineer the cell for improved production of valuable proteins. In this review, the protein post-translational modification such as folding, trafficking, and secretion, steps that are traditionally studied in isolation will here be described in the context of the whole system of protein secretion. Furthermore, examples of engineering secretion pathways, high-throughput screening and systems biology applications of studying protein production and secretion are also given to show how the protein production can be improved by different approaches. The objective of the review is to describe individual biological processes in the context of the larger, complex protein synthesis network.
机译：酵母酿酒酵母是一种广泛用于生产燃料和化学品的细胞工厂，它还提供了一个平台，可用于生产许多医学或工业上感兴趣的异源蛋白质。因此，许多研究都集中在代谢工程S. [NON-BREAKING SPACE]酿酒酵母上，以提高重组蛋白的产量，并且随着系统生物学的发展，有趣的是，该方法如何同时应用于进一步了解蛋白质的生产和分泌，并进一步改造细胞以提高有价值的蛋白质的产量。在这篇综述中，蛋白质的翻译后修饰，例如折叠，运输和分泌，这些是传统上单独研究的步骤，将在整个蛋白质分泌系统的背景下进行描述。此外，还提供了工程分泌途径，高通量筛选以及研究蛋白质产生和分泌的系统生物学应用的实例，以显示如何通过不同方法改善蛋白质产生。审查的目的是在较大的复杂蛋白质合成网络的背景下描述各个生物学过程。

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