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首页> 外文期刊>Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society >Genetic analysis of human embryos by metaphase comparative genomic hybridization (mCGH) improves efficiency of IVF by increasing embryo implantation rate and reducing multiple pregnancies and spontaneous miscarriages.
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Genetic analysis of human embryos by metaphase comparative genomic hybridization (mCGH) improves efficiency of IVF by increasing embryo implantation rate and reducing multiple pregnancies and spontaneous miscarriages.

机译：通过中期比较基因组杂交（mCGH）对人类胚胎进行遗传分析，可通过提高胚胎着床率，减少多次怀孕和自然流产来提高IVF的效率。

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OBJECTIVE: To assess the benefit of selecting blastocysts for cryotransfer based upon prior comparative genomic hybridization (CGH) karyotyping of blastomeres derived from their cleaved embryos of origin. Implantation and birth rates per transfer of previtrified CGH-tested blastocysts were compared with those following the transfer of nonCGH-tested fresh and warmed embryos. DESIGN: In vitro studies. SETTING: Private infertility clinic. PATIENT(S): Women undergoing infertility treatment. INTERVENTION(S): Three groups of women with similar clinical and demographic characteristics were compared. Group A underwent transfer of warmed blastocysts derived from CGH-normal day 3 embryos. Group B underwent embryo transfer of warmed blastocysts derived from nonkaryotyped vitrified embryos. Group C underwent fresh transfers with non-CGH-tested blastocysts. MAIN OUTCOME MEASURE(S): Implantation and birth rates per embryo after the cryotransfer of CGH-tested blastocysts. RESULT(S): The birth rate per transferred blastocyst in group A was 48%, versus 15% for group B and 19% for group C. The birth rate per embryo transfer was 60% for group A, and 33% for group B and 36% for group C. The miscarriage rate was 4% in group A, 8% in group B, and 12% in group C. CONCLUSION(S): The transfer of previously vitrified blastocysts derived from CGH-normal embryos significantly improves implantation and birth rates per embryo transferred and reduces the miscarriage rate. Vitrification does not compromise this enhancement.
机译：目的：基于事先比较的基因组杂交（CGH）对卵裂球起源于卵裂卵裂的染色体核型分析，评估选择用于低温转移的胚泡的益处。将每次玻璃化的经CGH测试的胚泡移植的植入率和出生率与未经CGH的新鲜和温暖胚胎移植后的植入率和出生率进行了比较。设计：体外研究。地点：私人不孕诊所。患者：正在接受不育治疗的妇女。干预措施：比较了三组具有相似临床和人口统计学特征的女性。 A组经历了从CGH正常的第3天胚胎衍生的温育胚泡的转移。 B组经历了从非核型化玻璃化胚胎衍生的温暖胚泡的胚胎移植。 C组接受未经CGH测试的胚泡进行新鲜转移。主要观察指标：经CGH测试的胚泡冷冻转移后，每个胚胎的植入率和出生率。结果：A组每次移植的胚泡出生率为48％，B组为15％，C组为19％。A组每次胚胎移植的出生率为60％，B组为33％ C组为36％。A组流产率为4％，B组为8％，C组为12％。结论：先前从CGH正常胚胎衍生的玻璃化胚泡的转移显着改善了植入以及每个胚胎移植的出生率，降低了流产率。玻璃化不会损害这种增强。

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