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首页> 外文期刊>Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society >Circulating and cellular adiponectin in polycystic ovary syndrome: relationship to glucose tolerance and insulin action.
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Circulating and cellular adiponectin in polycystic ovary syndrome: relationship to glucose tolerance and insulin action.

机译：多囊卵巢综合征中的循环脂联素和细胞脂联素：与葡萄糖耐量和胰岛素作用的关系。

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OBJECTIVE: To evaluate serum adiponectin levels and organization into multimers in women with polycystic ovary syndrome (PCOS) and assess relationships between adiponectin, glucose tolerance, and insulin resistance. DESIGN: In vivo and in vitro study. SETTING: Outpatient clinic at university and Veterans hospitals in the United States and university laboratory. PATIENT(S): Thirty-one obese women with PCOS and six age- and body mass index (BMI)-matched normal cycling control subjects. INTERVENTION(S): All subjects studied in the fasting state. MAIN OUTCOME MEASURE(S): A 75-g oral glucose tolerance test (OGTT), hyperinsulinemic/euglycemic clamp, circulating adiponectin levels, adipocyte adiponectin content, and organization of adiponectin into multimeric forms. RESULT(S): Whole body insulin action (glucose disposal rate, 5.61 +/- 2.90 vs. 8.79 +/- 0.81 mg/kg/min, PCOS and control) and adiponectin levels (9.5 +/- 0.7 7 vs. 17.4 +/- 1 microg/mL, PCOS vs. control) were significantly reduced in the subjects with PCOS. There were significant correlations between glucose tolerance, insulin action, and circulating adiponectin levels in all subjects. The content of adiponectin protein was reduced in subcutaneous adipocytes from subjects with PCOS (252 +/- 31 vs. 388 +/- 58 arbitrary units/10 microg protein). Subjects with PCOS had less of their circulating adiponectin organized into high molecular weight (HMW) multimeric complexes. Glucose-intolerant subjects with PCOS also had less intracellular HMW adiponectin. CONCLUSION(S): Both circulating adiponectin levels and the portion present as the most active HMW form are reduced in PCOS, with differences related to the degree of glucose intolerance and insulin resistance.
机译：目的：评估多囊卵巢综合征（PCOS）妇女的血清脂联素水平和组织成多聚体，并评估脂联素，葡萄糖耐量和胰岛素抵抗之间的关系。设计：体内和体外研究。地点：美国大学和退伍军人医院的门诊以及大学实验室。患者：31名患有PCOS的肥胖妇女和6名年龄和体重指数（BMI）相匹配的正常自行车控制对象。干预：所有受试者均处于禁食状态。主要观察指标：75 g口服葡萄糖耐量试验（OGTT），高胰岛素/正常血糖钳夹，循环脂联素水平，脂肪细胞脂联素含量和脂联素组织成多聚体形式。结果：全身胰岛素作用（葡萄糖处置率，5.61 +/- 2.90与8.79 +/- 0.81 mg / kg / min，PCOS和对照）和脂联素水平（9.5 +/- 0.7 7与17.4 +在患有PCOS的受试者中，PCOS相对于对照组的1μg/ mL明显降低。在所有受试者中，糖耐量，胰岛素作用和循环脂联素水平之间存在显着相关性。患有PCOS的受试者的皮下脂肪细胞中脂联素蛋白的含量降低（252 +/- 31与388 +/- 58任意单位/ 10 microg蛋白）。患有PCOS的受试者体内循环脂联素的组织较少，形成高分子量（HMW）多聚体复合物。患有PCOS的不耐葡萄糖受试者也具有较少的细胞内HMW脂联素。结论：在PCOS中，循环脂联素水平和以最活跃的HMW形式存在的部分均降低，其差异与葡萄糖耐量和胰岛素抵抗程度有关。

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