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首页> 外文期刊>Food & Function >Vitamin C exerts beneficial hepatoprotection against Concanavalin A-induced immunological hepatic injury in mice through inhibition of NF-kappa B signal pathway
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Vitamin C exerts beneficial hepatoprotection against Concanavalin A-induced immunological hepatic injury in mice through inhibition of NF-kappa B signal pathway

机译：维生素C通过抑制NF-κB信号传导途径对小鼠伴刀豆球蛋白A诱发的免疫性肝损伤发挥有益的肝保护作用

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The present study was designed to investigate the potential benefits of vitamin C (VC) in treating immunological liver injury induced by Concanavalin A (Con A, 20 mg kg(-1)) in mice. Interestingly, VC administration significantly reduced serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total-bilirubin (T-bilirubin) in Con A-lesioned mice, while serum concentrations of albumin and total-protein (T-protein) were increased. Moreover, inflammatory cytokine profiles, such as interferon-gamma (IFN-gamma), interleukin-4 (IL-4), interleukin-6 (IL-6) and interleukin-8 (IL-8), were decreased in liver tissue by VC administration. Morphological examination showed that Con A-induced liver damage was effectively mitigated. As shown in RT-PCR assay, VC administration resulted in down-regulated mRNA expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). In addition, VC contributed towards the reduction of intrahepatic tumor necrosis factor alpha (TNF-alpha) and the receptor (TNF-R) protein levels, as well as decreasing IKK beta, p-I kappa B alpha, p50 and NF-kappa B expressions; furthermore, VC blocked intranuclear DNA-binding NF-kappa B locus. Our findings show that VC effectively attenuates Con A-mediated immunotoxicity in liver tissue, through an underlying mechanism which relates to dampening of the intrahepatic NF-kappa B signal pathway, thereby reducing cytotoxicity within hepatocytes
机译：本研究旨在研究维生素C（VC）在治疗小鼠伴刀豆球蛋白A（Con A，20 mg kg（-1））引起的免疫性肝损伤中的潜在益处。有趣的是，VC给药可显着降低Con A损伤小鼠的血清丙氨酸转氨酶（ALT），天冬氨酸转氨酶（AST）和总胆红素（T-胆红素），而血清白蛋白和总蛋白（T-蛋白）增加了。此外，通过降低肝脏组织中的炎性细胞因子谱，例如干扰素-γ（IFN-γ），白介素-4（IL-4），白介素-6（IL-6）和白介素8（IL-8）。 VC管理。形态学检查表明，Con A诱导的肝损伤得到了有效缓解。如RT-PCR分析所示，VC给药导致环氧合酶2（COX-2）和诱导型一氧化氮合酶（iNOS）的mRNA表达下调。此外，VC有助于减少肝内肿瘤坏死因子α（TNF-alpha）和受体（TNF-R）蛋白水平，以及降低IKK beta，p-IκB alpha，p50和NF-κB表达;此外，VC阻断了核内结合DNA的NF-κB基因座。我们的发现表明，VC通过与抑制肝内NF-κB信号通路相关的潜在机制有效减弱了Con A介导的肝组织免疫毒性，从而降低了肝细胞内的细胞毒性。

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