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Compartment boundaries Sorting cells with tension

机译：隔室边界按张力分选细胞

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摘要

T he subdivision of proliferating tissues into groups of non-intermingling sets of cells, termed compartments, is a common process of animal-development. Signaling between adjacent compartments induces the local expression of morphogens that pattern the surrounding tissue. Sharp and straight boundaries between compartments stabilize the source of such morphogens during tissue growth and, thus, are of crucial importance for pattern formation. Signaling pathways required to maintain compartment boundaries have been identified, yet the physical mechanisms that maintain compartment boundaries remained elusive. Recent data now show that a local increase in actomyosin-based mechanical tension on cell bonds is vital for maintaining compartment boundaries in Drosophila.
机译：将增生的组织细分为一组不相交的细胞，称为隔室，是动物发育的常见过程。相邻隔室之间的信号传导会诱导形成周围组织的形态发生子的局部表达。隔室之间的尖锐且笔直的边界在组织生长过程中稳定了此类形态发生素的来源，因此，对于图案形成至关重要。已经确定了维持隔室边界所需的信号通路，但是维持隔室边界的物理机制仍然难以捉摸。现在的最新数据表明，基于肌动球蛋白的机械键在细胞键上的局部升高对于维持果蝇的区室边界至关重要。

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