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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Effects of luteal estradiol pre-treatment on the outcome of IVF in poor ovarian responders
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Effects of luteal estradiol pre-treatment on the outcome of IVF in poor ovarian responders

机译：黄体雌二醇预处理对卵巢反应不良的IVF结局的影响

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Background: In view of the discrepancies about the luteal estradiol treatment before stimulation protocols having some potential advantages compared with the standard protocols in poor ovarian responders undergoing IVF, a meta-analysis of the published data was performed to compare the efficacy of the luteal estradiol pre-treatment protocols in IVF poor response patients. Methods: We searched for all published articles. The searches yielded 32 articles, from which seven studies met the inclusion criteria. We performed this meta-analysis involving 450 IVF patients in luteal estradiol pre-treatment protocol group and 606 patients in standard protocol group. Results: The luteal estradiol protocol resulted in a significantly higher duration of stimulation compared with the standard protocol. In addition, the number of oocytes retrieved and mature oocytes retrieved were significantly higher in the luteal estradiol protocols than those in the standard protocols. The cycle cancellation rate (CCR) in the luteal estradiol protocols was lower than the standard protocols. Moreover, no significant difference was found in the clinical pregnancy rate (CPR). Conclusions: The addition of the estradiol in the luteal phase preceding IVF in poor responders improved IVF cycle outcomes, including increasing the number of oocytes retrieved and mature oocytes retrieved and decreasing the CCR. ? 2013 Informa UK, Ltd.
机译：背景：鉴于在接受IVF的卵巢不良反应者中，刺激方案之前黄体雌二醇治疗与标准方案相比具有一些潜在优势，因此对已发表的数据进行了荟萃分析，以比较黄体雌二醇前体治疗的有效性。 IVF反应不良患者的治疗方案。方法：我们搜索了所有已发表的文章。搜索产生了32篇文章，其中7篇研究符合纳入标准。我们进行了这项荟萃分析，涉及黄体雌二醇预处理方案组的450名IVF患者和标准方案组的606名患者。结果：与标准方案相比，黄体雌二醇方案可显着延长刺激时间。此外，黄体雌二醇方案中回收的卵母细胞和成熟卵母细胞的数量明显高于标准方案。黄体雌二醇方案的循环消除率（CCR）低于标准方案。此外，在临床妊娠率（CPR）上没有发现显着差异。结论：在IVF较差的应答者之前，在黄体期添加雌二醇可改善IVF周期结果，包括增加回收的卵母细胞数量和成熟的卵母细胞数量并降低CCR。 ？ 2013 Informa UK，Ltd.

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