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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Changes of serum cytokines-related Th1/Th2/Th17 concentration in patients with postmenopausal osteoporosis
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Changes of serum cytokines-related Th1/Th2/Th17 concentration in patients with postmenopausal osteoporosis

机译：绝经后骨质疏松症患者血清细胞因子相关的Th1 / Th2 / Th17浓度的变化

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摘要

Postmenopausal osteoporosis is now hypothetically considered to be an autoimmune and inflammatory process in which many proTinflammatory and T cell-derived cytokines play important roles in the loss of bone mass. For instance, interleukin-2 (IL-2), interferon-y (IFN-y), and tumor necrosis factor-a (TNF-a) secreted by Th1 and IL-6, IL-4, and IL-10 secreted by Th2 have been shown to be involved in the pathogenesis of osteoporosis. lnterleukin-17 (IL-17) is a characteristic cytokine secreted byTh17 cells of the CD4 +subgroup. Although IL-17 has been shown to enhance bone resorption in ovariectomized mouse model, bone cells and genetic research, human-related studies of IL-17 are few.
机译：现已假设绝经后骨质疏松症是一种自身免疫和炎症过程，其中许多促炎性和T细胞源性细胞因子在骨量损失中起重要作用。例如，Th1分泌的白介素-2（IL-2），干扰素-γ（IFN-y）和肿瘤坏死因子-a（TNF-a）以及Th1分泌的IL-6，IL-4和IL-10已显示Th2与骨质疏松症的发病机理有关。白介素-17（IL-17）是CD4 +亚组的Th17细胞分泌的特征性细胞因子。尽管已显示IL-17在去卵巢小鼠模型，骨细胞和遗传研究中可增强骨吸收，但与人相关的IL-17研究很少。

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