...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Recurrent miscarriage and hCG supplementation: a review and metaanalysis.
【24h】

Recurrent miscarriage and hCG supplementation: a review and metaanalysis.

机译：反复流产和hCG补充：回顾和荟萃分析。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Human chorionic gonadotropin (hCG) has been used to prevent subsequent miscarriages after previous recurrent miscarriages. In addition to the luteotrophic effects, hCG has uterine immune and autocrine actions. hCG also affects cytokine expression. A Cochrane database systematic review has indicated that hCG seems to prevent further miscarriages, (OR for miscarriage = 0.26, 95% CI 0.14-0.52). However, the trials in the Cochrane database were not matched for the number of miscarriages, 1 degrees , 2 degrees or 3 degrees aborter status, maternal age, etc. and no account was made for chromosomally abnormal pregnancies. All of these impact on the subsequent prognosis and may confound the results. The previous trials in the literature all assessed urinary (u-hCG) rather than recombinant hCG (r-hCG), raising the question whether the effect on pregnancy outcome is due to hCG itself, or other urinary proteins present in u-hCG. A new trial is indicated in which r-hCG is compared to u-hCG and the most effective compared to placebo. Treatment and placebos arms should be stratified for the prognostic factors above and the results corrected for fetal chromosomal aberrations. Until such a trial is carried out, the use of hCG supplementation is empiric.
机译：人绒毛膜促性腺激素（hCG）已用于预防先前反复流产后的后续流产。除促营养作用外，hCG还具有子宫免疫和自分泌作用。 hCG也影响细胞因子的表达。 Cochrane数据库的系统评价表明，hCG似乎可以防止进一步的流产（流产的OR值为0.26，95％CI为0.14-0.52）。但是，Cochrane数据库中的试验在流产次数，1度，2度或3度流产状况，产妇年龄等方面均不匹配，也没有考虑染色体异常妊娠。所有这些都会影响后续的预后，并可能混淆结果。文献中先前的试验均评估了尿液（u-hCG）而非重组hCG（r-hCG），这引发了对妊娠结局的影响是否归因于hCG本身或u-hCG中存在的其他尿蛋白的问题。指示了一项新的试验，其中将r-hCG与u-hCG进行比较，并且与安慰剂进行比较最有效。对于上述预后因素，应对治疗和安慰剂组进行分层，并针对胎儿染色体畸变校正结果。在进行此类试验之前，使用hCG补充剂是经验性的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号