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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Myometrial oxytocin receptor mRNA concentrations at preterm and term delivery - the influence of external oxytocin.
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Myometrial oxytocin receptor mRNA concentrations at preterm and term delivery - the influence of external oxytocin.

机译：早产和足月分娩时子宫肌层催产素受体mRNA的浓度-外部催产素的影响。

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The hormonal system for induction of term and preterm labour is not fully understood. Therefore, we investigated myometrial gene expressions for neurohypophyseal hormones and their receptors, prostaglandin F(2alpha) and ovarian steroid receptors in women delivered by Caesarean section. Myometrial tissue for real time PCR was collected from 39 women delivered at term before and after the onset of labour and preterm. Women delivered electively at term had significantly higher oxytocin receptor mRNA expressions (2.52 +/- 0.37 oxytocin receptor/actin; median +/- SEM) than those delivered with ongoing labour at term (1.01 +/- 0.34; p = 0.015) and those at preterm (1.08 +/- 0.25; p = 0.004). Sub-analyses revealed that the difference at term pregnancies solely was related to patients receiving oxytocin during labour (p = 0.007). These patients had higher oxytocin peptide mRNA levels than those without labour at term (p = 0.009). PGF(2alpha) receptor mRNA concentrations were 27.80 +/- 3.55, 11.46 +/- 2.87 and 19.54 +/- 5.52 PGF receptor/actin, respectively, for the groups. Women without labour at term had higher concentration than those with labour (p = 0.005). Our results suggest that oxytocin, its receptor and the PGF(2alpha) receptor are involved in the regulation of labour through a paracrine mechanism.
机译：诱导足月和早产的荷尔蒙系统尚未完全了解。因此，我们调查了剖宫产妇女的神经下垂体激素及其受体，前列腺素F（2alpha）和卵巢类固醇受体的子宫肌层基因表达。实时PCR的子宫肌层组织是从分娩前后和早产期间足月分娩的39名妇女中收集的。足月分娩的妇女的催产素受体mRNA表达（2.52 +/- 0.37催产素受体/肌动蛋白;中位数+/- SEM）明显高于足月进行分娩的妇女（1.01 +/- 0.34; p = 0.015）。早产（1.08 +/- 0.25; p = 0.004）。次分析表明，足月妊娠的差异仅与分娩期间接受催产素的患者有关（p = 0.007）。与足月无劳动者相比，这些患者的催产素肽mRNA水平更高（p = 0.009）。对于各组，PGF（2α）受体mRNA的浓度分别为27.80 +/- 3.55、11.46 +/- 2.87和19.54 +/- 5.52 PGF受体/肌动蛋白。足月无劳动的妇女比有劳动的妇女集中度更高（p = 0.005）。我们的结果表明催产素，其受体和PGF（2alpha）受体通过旁分泌机制参与劳动的调节。

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