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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >The protective effect of the ER22/23EK polymorphism against an excessive weight gain during pregnancy.
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The protective effect of the ER22/23EK polymorphism against an excessive weight gain during pregnancy.

机译：ER22 / 23EK基因多态性对怀孕期间体重过度增加的保护作用。

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摘要

It has been shown that women who gained an excessive weight during pregnancy had an increase in long-term BMI compared with those without an excessive weight gain. Several studies have demonstrated that some polymorphisms of the glucocorticoid receptor (GR) gene may influence body composition and metabolic parameters. In the present study, we wanted to explore whether any association could exist between the BclI, N363S and ER22/23EK polymorphisms of the GR gene and the weight gain during pregnancy. We found that the allelic frequencies of the BclI, N363S and ER22/23EK polymorphisms in 300 women with uncomplicated pregnancies were similar to those measured in healthy Hungarian population. None of the three polymorphisms associated with body weight or BMI at the 1st trimester of pregnancy or before delivery. However, a significantly lower weight gain (p = 0.044) and consequently lower increase of BMI during pregnancy (p = 0.044) was observed in heterozygous carriers of the ER22/23EK polymorphism. These results support a protective role of the ER22/23EK polymorphism against an excessive weight gain and excessive increase of BMI during uncomplicated pregnancy.
机译：研究表明，与没有过度增加体重的女性相比，怀孕期间过度增加体重的女性的长期BMI有所增加。多项研究表明，糖皮质激素受体（GR）基因的某些多态性可能会影响人体成分和代谢参数。在本研究中，我们想探讨GR基因的BclI，N363S和ER22 / 23EK多态性与怀孕期间体重增加之间是否存在任何关联。我们发现在300例未发生妊娠的孕妇中，BclI，N363S和ER22 / 23EK多态性的等位基因频率与在匈牙利健康人群中测得的频率相似。妊娠中期或分娩前与体重或BMI相关的三种多态性均没有。但是，在ER22 / 23EK多态性杂合子携带者中，观察到体重增加显着较低（p = 0.044），因此孕期BMI升高较低（p = 0.044）。这些结果支持了ER22 / 23EK基因多态性对单纯性妊娠期间体重过度增加和BMI过度增加的保护作用。

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