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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Optimizing hormone therapy for future reproductive performance in women with premature ovarian failure.
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Optimizing hormone therapy for future reproductive performance in women with premature ovarian failure.

机译：优化荷尔蒙治疗，以使卵巢早衰的女性将来获得更好的生殖能力。

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摘要

With increasing success in treatment of childhood cancer there is a growing population of women with premature ovarian failure (POF) seeking fertility treatment. Various preparations of estrogen and progestogen are prescribed for young women with POF. While the dose and duration of hormone therapy (HT) is usually adjusted according to the patient's height and the Tanner's stage of development for young pre-pubertal women, the optimal effective HT regimen to maximise the reproductive potential for young as well as for the older age group remains unclear. Furthermore, there is a paucity of evidence to support the preferential effectiveness of the different regimens used. Assisted reproduction using donated gametes or embryos remains the only realistic option to enable women with POF to conceive. Successful outcomes are primarily dependant on successful implantation and placentation. Consequently, the success of assisted reproduction is determined by uterine and endometrial development, which is largely influenced by the modality of HT as well as the age at which it is commenced. In this review, we critically appraise the current practices and published data for management of women with POF. We aim to focus on the effect of HT on uterine development in women with primary and irreversible POF.
机译：随着儿童期癌症治疗成功率的提高，越来越多的卵巢早衰（POF）妇女寻求生育治疗。对于患有POF的年轻女性，处方了各种雌激素和孕激素制剂。尽管通常根据患者的身高和年轻的青春期前女性的Tanner发育阶段来调整激素治疗（HT）的剂量和持续时间，但最佳的有效HT方案可以最大限度地提高年轻人和老年人的生殖潜能年龄组仍不清楚。此外，没有足够的证据支持所使用的不同方案的优先效力。使用捐赠的配子或胚胎进行辅助生殖仍然是使患有POF的女性受孕的唯一现实选择。成功的结局主要取决于成功的植入和胎盘植入。因此，辅助生殖的成功取决于子宫和子宫内膜的发育，而子宫和子宫内膜的发育在很大程度上受HT的方式及其开始的年龄的影响。在这篇评论中，我们严格评估了POF妇女管理的当前做法和已发布的数据。我们旨在集中研究HT对原发性和不可逆POF妇女子宫发育的影响。

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