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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >The molecular and genetic aspects of adolescent girls anomalous uterine bleeding: the role of endothelial dysfunction syndrome
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The molecular and genetic aspects of adolescent girls anomalous uterine bleeding: the role of endothelial dysfunction syndrome

机译：少女子宫异常出血的分子和遗传学方面：内皮功能障碍综合征的作用

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摘要

The objective of the study is to assess NOS3 and ESR1 gene polymorphism in adolescent girls born with low birth weight (LBW) and suffered by anomalous uterine bleeding (AUB). A total 95 adolescent girls were studied including 32 born with LBW and AUB; 36 girls with normal birth weight and AUB; and 27 healthy girls. Single allele gene polymorphism NOS3 786T>C, 894G>T, ESR1 351A>G and 397T>C was studied. The existence of polymorphous allele C gene NOS3 786?>C (for homozygote OR=2.03; 95% CI: 1.12-3.68; p=0.04; for heterozygote OR=1.68; 95% CI: 1.09-2.60; p=0.046) and genotype Pvull-CC ESR1 (OR=4.58; 95% CI: 0.97-21.68; p=0.04) was detected in LBW girls with AUB. It was suggested that intrauterine programming of endothelial dysfunction syndrome could play a significant role in the development of AUB in adolescent girls born with LBW.
机译：这项研究的目的是评估出生时体重低（LBW），子宫异常出血（AUB）的少女的NOS3和ESR1基因多态性。共研究了95名青春期女孩，其中32名出生于LBW和AUB。 36名出生体重和AUB正常的女孩;和27个健康的女孩。研究了单等位基因基因多态性NOS3 786T> C，894G> T，ESR1 351A> G和397T> C。多态等位基因C基因NOS3 786→C的存在（对于纯合子OR = 2.03; 95％CI：1.12-3.68; p = 0.04;对于杂合子OR = 1.68; 95％CI：1.09-2.60; p = 0.046）在患有AUB的LBW女孩中检测到基因型Pvull-CC ESR1（OR = 4.58; 95％CI：0.97-21.68; p = 0.04）。有人提出，子宫内血管内皮功能障碍综合征的宫内程序设计可能在出生体重不足的少女中AUB的发生中起重要作用。

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