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首页> 外文期刊>Forensic science international >Driving under the influence of drugs - evaluation of analytical data of drugs in oral fluid, serum and urine, and correlation with impairment symptoms.
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Driving under the influence of drugs - evaluation of analytical data of drugs in oral fluid, serum and urine, and correlation with impairment symptoms.

机译：在药物影响下驾驶-评估口服液，血清和尿液中药物的分析数据，以及与损伤症状的相关性。

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A study was performed to acquire urine, serum and oral fluid samples in cases of suspected driving under the influence of drugs of abuse. Oral fluid was collected using a novel sampling/testing device (Drager DrugTest((R)) System). The aim of the study was to evaluate oral fluid and urine as a predictor of blood samples positive for drugs and impairment symptoms. Analysis for cannabinoids, amphetamine and its derivatives, opiates and cocaine was performed in urine using the Mahsan Kombi/DOA4-test, in serum using immunoassay and gas chromatography-mass spectrometry (GC-MS) confirmation and in oral fluid by GC-MS. Police and medical officer observations of impairment symptoms were rated and evaluated using a threshold value for the classification of driving inability. Accuracy in correlating drug detection in oral fluid and serum were >90% for all substances and also >90% in urine and serum except for THC (71.0%). Of the cases with oral fluid positive for any drug 97.1% of corresponding serum samples were also positive for at least one drug; of drug-positive urine samples this were only 82.4%. In 119 of 146 cases, impairment symptoms above threshold were observed (81.5%). Of the cases with drugs detected in serum, 19.1% appeared not impaired which were the same with drug-positive oral fluid while more persons with drug-positive urine samples appeared uninfluenced (32.7%). The data demonstrate that oral fluid is superior to urine in correlating with serum analytical data and impairment symptoms of drivers under the influence of drugs of abuse.
机译：进行了一项研究，以在滥用药物的影响下怀疑驾驶的情况下采集尿液，血清和口腔液体样品。使用新型采样/测试装置（Drager DrugTest系统）收集口腔液。该研究的目的是评估口服液和尿液，以预测药物和损伤症状阳性的血样。使用Mahsan Kombi / DOA4-test对尿液中的大麻素，苯丙胺及其衍生物，鸦片剂和可卡因进行分析，使用免疫测定法和气相色谱-质谱法（GC-MS）确证在血清中进行分析，并通过GC-MS对口腔液进行分析。警察和医务人员对障碍症状的观察结果被评估，并使用阈值对驾驶不便进行分类。除四氢大麻酚（71.0％）外，所有物质在口服液和血清中相关药物检测的准确性均> 90％，在尿液和血清中也> 90％。在任何一种药物的口服液阳性的病例中，相应的血清样本中97.1％的至少一种药物也呈阳性。在药物阳性尿液样本中，这一比例仅为82.4％。 146例病例中有119例观察到损伤症状超过阈值（81.5％）。在血清中检测到药物的病例中，有19.1％的人似乎没有受损，这与药物阳性的口服液相同，而更多的具有药物阳性的尿液样本的人似乎没有受到影响（32.7％）。数据表明，在滥用药物的影响下，口服液优于尿液与血清分析数据和驾驶员损伤症状相关。

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