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首页> 外文期刊>Folia histochemica et cytobiologica >Proliferative activity of gastric epithelial cells in Helicobacter pylori infected children.
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Proliferative activity of gastric epithelial cells in Helicobacter pylori infected children.

机译：幽门螺杆菌感染儿童的胃上皮细胞的增殖活性。

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摘要

Helicobacter pylori infection has been associated with gastric carcinogenesis. Gastric epithelial cells proliferative rate is accelerated in H. pylori infected adult patients. Our study was performed to evaluate proliferative cell activity in gastric epithelium in the course of H. pylori infection in the early stage of its natural history. Gastric antral biopsy specimens were obtained from thirteen H. pylori positive and seven negative children. To assess replication rates we used nucleolar organiser regions staining with colloidal silver nitrate technique (AgNOR). The number of AgNORs per nucleus, area of single AgNOR, and the quotient of these two parameters (AgNOR content) were analysed. The mean area of AgNOR was lower in H. pylori positive than in negative children. Conversely, both the mean number of AgNOR per nucleus and AgNOR content were higher in infected than non infected subjects. These results show accelerated proliferation of gastric antral epithelial cells in the course of H. pylori infection in children. Such alteration of cell replication occurring in an initial phase of natural history of long lasting infection provides an explanation for the association between acquisition of H. pylori infection in the first years of life and the development of gastric cancer.
机译：幽门螺杆菌感染与胃癌发生有关。在幽门螺杆菌感染的成年患者中，胃上皮细胞的增殖速度加快。我们的研究旨在评估幽门螺杆菌自然史早期感染过程中胃上皮细胞的增殖活性。从13例幽门螺杆菌阳性和7例阴性儿童中获得胃肛门活检标本。为了评估复制率，我们使用了胶态硝酸银技术（AgNOR）的核仁组织区染色。分析了每个核的AgNOR数，单个AgNOR的面积以及这两个参数的商（AgNOR含量）。幽门螺杆菌阳性的AgNOR平均面积低于阴性儿童。相反，受感染个体的平均每个细胞核平均AgNOR数和AgNOR含量均高于未感染个体。这些结果表明，在儿童幽门螺杆菌感染的过程中，胃窦上皮细胞的增殖加速。这种在长期感染的自然史的初始阶段发生的细胞复制改变为生命最初几年获得幽门螺杆菌感染与胃癌发展之间的关联提供了解释。

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