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首页> 外文期刊>Folia histochemica et cytobiologica >Coexpression of PTHrP and PTH/PTHrP receptor in a myoepithelial cell line derived from normal human breast.
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Coexpression of PTHrP and PTH/PTHrP receptor in a myoepithelial cell line derived from normal human breast.

机译：PTHrP和PTH / PTHrP受体在源自正常人乳房的肌上皮细胞系中的共表达。

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摘要

Parathyroid hormone-related peptide (PTHrP) is the cause of humoral hipercalcaemia of malignancy syndrome (HHM). It is known that the peptide as well as its receptors are widely distributed in many normal organs and tissues, where it influences an array of diverse functions which are realized through paracrine or autocrine pathway. PTHrP is present in large amounts in lactating mammary gland but its function is not fully elucidated. In this study, production of parathyroid hormone-related peptide (PTHrP) by the Hs578Bst cell line corresponding to mammary myoepithelial cells was examined by immunocytochemistry. Using RNA extracted from these cells we analyzed expression of mRNA for PTHrP and for the PTH/PTHrP receptor by RT-PCR. The obtained results demonstrated that Hs578Bst cells produced PTHrP and synthesized mRNA for PTHrP and PTH/PTHrP type I receptor. It provides evidence that myoepithelial cells are target cells for PTHrP. The data support that PTHrP may be an important autocrine/paracrine factor, involved in the regulation of myoepithelial cell function as well as in growth and differentiation of the mammary gland.
机译：甲状旁腺激素相关肽（PTHrP）是恶性肿瘤综合征（HHM）体液性髋钙血症的原因。已知该肽及其受体广泛分布在许多正常器官和组织中，在那里它影响通过旁分泌或自分泌途径实现的多种功能。 PTHrP大量存在于泌乳的乳腺中，但其功能尚未完全阐明。在这项研究中，通过免疫细胞化学检查了对应于乳腺肌上皮细胞的Hs578Bst细胞系产生的甲状旁腺激素相关肽（PTHrP）。使用从这些细胞中提取的RNA，我们通过RT-PCR分析了PTHrP和PTH / PTHrP受体的mRNA表达。获得的结果证明，Hs578Bst细胞产生PTHrP并合成PTHrP和PTH / PTHrP I型受体的mRNA。它提供了证据表明肌上皮细胞是PTHrP的靶细胞。数据支持PTHrP可能是重要的自分泌/旁分泌因子，参与肌上皮细胞功能的调节以及乳腺的生长和分化。

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