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首页> 外文期刊>Folia histochemica et cytobiologica >Anaerobic bacteria colonizing the lower airways in lung cancer patients
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Anaerobic bacteria colonizing the lower airways in lung cancer patients

机译：厌氧菌在肺癌患者的下呼吸道定植

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Anaerobes comprise most of the endogenous oropharyngeal microflora, and can cause infections of airways in lung cancer patients who are at high risk for respiratory tract infections. The aim of this study was to determine the frequency and species diversity of anaerobes in specimens from the lower airways of lung cancer patients. Sensitivity of the isolates to conventional antimicrobial agents used in anaerobe therapy was assessed. Respiratory secretions obtained by bronchoscopy from 30 lung cancer patients were cultured onto Wilkins- -Chalgren agar in anaerobic conditions at 37°C for 72-96 hours. The isolates were identified using microtest Api 20A. The minimal inhibitory concentrations for penicillin G, amoxicillin/clavulanate, piperacillin/tazobactam, cefoxitin, imipenem, clindamycin, and metronidazole were determined by E-test. A total of 47 isolates of anaerobic bacteria were detected in 22 (73.3%) specimens. More than one species of anaerobe was found in 16 (53.3%) samples. The most frequently isolated were Actinomyces spp. and Peptostreptococcus spp., followed by Eubacterium lentum, Veillonella parvula, Prevotella spp., Bacteroides spp., Lactobacillus jensenii. Among antibiotics used in the study amoxicillin/clavulanate and imipenem were the most active in vitro (0% and 2% resistant strains, respectively). The highest resistance rate was found for penicillin G and metronidazole (36% and 38% resistant strains, respectively). The results obtained confirm the need to conduct analyses of anaerobic microflora colonizing the lower respiratory tract in patients with lung cancer to monitor potential etiologic factors of airways infections, as well as to propose efficient, empirical therapy.
机译：厌氧菌包括大多数内源性口咽微生物区系，并且可以在具有呼吸道感染高风险的肺癌患者中引起气道感染。这项研究的目的是确定肺癌患者下呼吸道标本中厌氧菌的频率和种类多样性。评估了分离株对厌氧菌治疗中使用的常规抗菌剂的敏感性。通过支气管镜检查从30名肺癌患者中获得的呼吸道分泌物在厌氧条件下于37°C在Wilkins-Chalgren琼脂上培养72-96小时。使用微量测试的Api 20A鉴定分离株。通过E-检验确定对青霉素G，阿莫西林/克拉维酸盐，哌拉西林/他唑巴坦，头孢西丁，亚胺培南，克林霉素和甲硝唑的最低抑制浓度。在22个（73.3％）标本中共检出47株厌氧菌。在16个样本（53.3％）中发现了一种以上的厌氧菌。最常分离的是放线菌属。依次为扁杆菌，小菜蛾，普氏杆菌，拟杆菌，詹森氏乳杆菌。在这项研究中使用的抗生素中，阿莫西林/克拉维酸盐和亚胺培南在体外最活跃（分别为0％和2％耐药菌株）。青霉素G和甲硝唑的耐药率最高（分别为36％和38％耐药菌株）。获得的结果证实，有必要对肺癌患者下呼吸道中的无氧菌群进行分析，以监测气道感染的潜在病因，并提出有效的经验疗法。

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