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首页> 外文期刊>Folia histochemica et cytobiologica >Benzalkonium chloride (BAK) induces apoptosis or necrosis, but has no major influence on the cell cycle of Jurkat cells
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Benzalkonium chloride (BAK) induces apoptosis or necrosis, but has no major influence on the cell cycle of Jurkat cells

机译：苯扎氯铵（BAK）诱导凋亡或坏死，但对Jurkat细胞的细胞周期没有重大影响

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摘要

Benzalkonium chloride (BAK) is a cationic detergent with a very slow turnover. Because of its strong antibacterial activities, BAK is widely used especially in dentistry and ophthalmology. It is the most commonly used preservative in topical ophthalmic medications. Due to chronicity and widespread use of such treatments, BAK's side effects are of great importance. BAK toxicity for adherent cells, probably related to its pro-oxidative activities, is time- and dose-dependent. Although lymphocytes often infiltrate superficial eye tissues, the BAK influence on them is yet to be established. The aim of this study was to check BAK cytotoxicity on T lymphocytic Jurkat line cells and to verify the suggestion that BAK can induce G2M cell blocks. A dose- and time-dependent cytotoxic effect of BAK on lymphoid cells in relatively low concentrations was shown in this study. In lower concentrations, it shows a moderate apoptotic and minimal antiproliferative effect on Jurkat cells, while in higher concentrations it shows a rapid necrotic effect. No G2M cell blocks were observed. Our findings could suggest lymphoid dysfunction during intensive, prolonged topical BAK treatment, even at dosages relatively non-toxic to epithelial eye cells.
机译：苯扎氯铵（BAK）是一种周转非常慢的阳离子洗涤剂。由于其强大的抗菌活性，BAK特别是在牙科和眼科领域得到广泛使用。它是局部眼科药物中最常用的防腐剂。由于慢性和这种疗法的广泛使用，BAK的副作用非常重要。 BAK对贴壁细胞的毒性（可能与其促氧化活性有关）取决于时间和剂量。尽管淋巴细胞经常浸润浅表眼组织，但BAK对它们的影响尚待确定。这项研究的目的是检查BAK对T淋巴细胞Jurkat细胞系的细胞毒性，并验证BAK可以诱导G2M细胞阻滞的暗示。在这项研究中显示了BAK对淋巴样细胞的剂量和时间依赖性的细胞毒性作用。在较低的浓度下，它对Jurkat细胞显示出中等程度的凋亡和最小的抗增殖作用，而在较高的浓度下，它表现出快速的坏死作用。没有观察到G2M细胞块。我们的发现可能表明，即使在对上皮眼细胞无毒的剂量下，长时间，长时间的局部BAK治疗也可能导致淋巴功能障碍。

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