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首页> 外文期刊>Forensic science international >Breath alcohol analysis incorporating standardization to water vapour is as precise as blood alcohol analysis
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Breath alcohol analysis incorporating standardization to water vapour is as precise as blood alcohol analysis

机译：结合了水蒸气标准化的呼吸酒精分析与血液酒精分析一样精确

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A novel breath-alcohol analyzer based on the standardization of the breath alcohol concentration (BrAC) to the alveolar-air water vapour concentration has been developed and evaluated. The present study compares results with this particular breath analyzer with arterial blood alcohol concentrations (ABAC), the most relevant quantitative measure of brain alcohol exposure. The precision of analysis of alcohol in arterial blood and breath were determined as well as the agreement between ABAC and BrAC over time post-dosing.Twelve healthy volunteers were administered 0.6. g. alcohol/kg bodyweight via an orogastric tube. Duplicate breath and arterial blood samples were obtained simultaneously during the absorption, distribution and elimination phases of the alcohol metabolism with particular emphasis on the absorption phase.The precision of the breath analyzer was similar to the determination of blood alcohol concentration by headspace gas chromatography (CV 2.40 vs. 2.38%, p=. 0.43). The ABAC/BrAC ratio stabilized 30. min post-dosing (2089 ± 99; mean ± SD). Before this the BrAC tended to underestimate the coexisting ABAC.In conclusion, breath alcohol analysis utilizing standardization of alcohol to water vapour was as precise as blood alcohol analysis, the present " gold standard" method. The BrAC reliably predicted the coexisting ABAC from 30. min onwards after the intake of alcohol.
机译：基于呼吸酒精浓度（BrAC）到肺泡空气水蒸气浓度的标准化的新型呼吸酒精分析仪已经开发和评估。本研究将这种特定的呼吸分析仪的结果与动脉血酒精浓度（ABAC）进行了比较，这是最相关的脑酒精暴露定量测量方法。确定了动脉血和呼气中酒精含量的分析准确性，以及ABAC和BrAC在服药后随时间变化的一致性。12名健康志愿者的血药浓度为0.6。 G。酒精/千克体重（通过胃胃管）。在酒精代谢的吸收，分布和消除阶段，同时获取了重复的呼吸和动脉血样，其中重点是吸收阶段。呼吸分析仪的精密度类似于通过顶空气相色谱法（CV）测定血液中的酒精浓度2.40比2.38％，p = 0.43）。给药后30分钟，ABAC / BrAC比率稳定（2089±99;平均值±SD）。总之，BrAC往往低估了并存的ABAC。总而言之，利用酒精对水蒸气的标准化对呼吸酒精进行的分析与目前的“黄金标准”方法血液酒精分析一样精确。 BrAC从摄入酒精后30分钟起可靠地预测了ABAC并存。

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