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首页> 外文期刊>Forensic science international >Prevalence of driving with blood drug concentrations above proposed new legal limits in Norway: estimations based on drug concentrations in oral fluid.
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Prevalence of driving with blood drug concentrations above proposed new legal limits in Norway: estimations based on drug concentrations in oral fluid.

机译：在挪威，血液中药物浓度超过提议的新法律限制的驾驶率：基于口服液中药物浓度的估计。

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AIM: To estimate the prevalence of driving with blood drug concentrations above the recently proposed Norwegian legal limits for drugged driving in random traffic. The results from a roadside survey of 10,816 drivers was used as basis for the estimation, and the most prevalent drugs were included. METHODS: Three approaches were used to estimate the prevalence of drug concentrations above the proposed legal limits in blood based on drug concentrations in oral fluid: comparison with drug concentrations observed in oral fluid and blood in pharmacokinetic studies, estimating the prevalence of drug concentrations in blood by calculating the prevalence of drug concentrations in oral fluid that were larger than the limit in blood multiplied with mean oral fluid/blood ratios, and a mathematical simulation mimicking the relationship between drug concentration distributions in blood and oral fluid for populations of drug users. RESULTS: In total, alcohol or drugs were detected in 5.7% of the samples of oral fluid from drivers in normal traffic; 3.8% (n=410) were positive for the drugs that we included in the assessment. The estimation of drug concentrations in blood suggested that about 1.5% had concentrations above the proposed legal limits in blood for the studied drugs, which is about 40% of those who were positive for the drugs in oral fluid. CONCLUSION: The estimated prevalence of driving with concentrations of psychoactive drugs in blood above the proposed legal limits was for illegal drugs 0.4% and for medicinal drugs 1.1%. These may be regarded as minimum estimates as some drugs were not included in the assessment. These prevalences are higher than the prevalence of driving with blood alcohol concentrations above the legal limit of 0.2g/kg in Norway.
机译：目的：评估血液中药物浓度超过最近提议的针对随机交通中的毒品驾驶的挪威法律限制的驾驶情况。对10,816名驾驶员的路边调查结果被用作估算的依据，其中包括了最流行的药物。方法：三种方法被用来根据口服液中的药物浓度来估算血液中高于法定法定限度的药物流行度：与药代动力学研究中观察到的口服液和血液中药物浓度的比较，估算血液中药物浓度的流行度通过计算比血液中的限值大的口腔液中药物浓度的患病率乘以平均口腔液/血比得出的结果，并通过数学模拟来模拟针对吸毒人群的血液和口腔液中药物浓度分布之间的关系。结果：在正常交通的驾驶员中，有5.7％的口腔液样本中检测到酒精或毒品;对于我们纳入评估的药物，有3.8％（n = 410）呈阳性。对血液中药物浓度的估计表明，约有1.5％的浓度高于研究药物的血液法定浓度上限，约占口服液中药物阳性者的40％。结论：血液中精神药物浓度高于建议的法定限值时，驾驶的估计患病率是：非法药物为0.4％，药用药物为1.1％。由于某些药物未包括在评估中，因此这些可能被视为最低估计。这些患病率高于挪威血液中酒精浓度超过法律规定的0.2g / kg的驾驶率。

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