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首页> 外文期刊>Evidence-based cardiovascular medicine >PC-coated stents and abciximab do not reduce restenosis more than angioplasty in small coronary vessels
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PC-coated stents and abciximab do not reduce restenosis more than angioplasty in small coronary vessels

机译：PC涂层支架和abciximab不会比小冠状动脉血管成形术减少再狭窄更多

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Background As the use of stents increases, so too does the incidence of in-stent restenosis. Each year, about two million percutaneous interventions are performed throughout the world. Clinical restenosis occurs in 12% to 15%, necessitating repeat revascu-larisation in 240,000 to 300,000 people each year. In early trials of stents, angiographic restenosis occurred in 15% to 20% of participants.However, as stenting was extended to more complex lesions and clinical groups, we learned that angiographic restenosis rates can reach 30% to 50% in complex lesions.Restenosis rates are higher in people with diabetes, small reference vessel diameters, and long lesions. A range of different techniques to reduce restenosis have been trialed, including coating stents with phosphorylcholine (PC).Objective Hausleiter and colleagues compared the effect on restenosis in small coronary arteries of PC-coated stents versus percutaneous transluminal coronary angioplasty (PTCA), with or without abciximab.The primary endpoint was incidence of angiographic restenosis (greater or equal to 50% diameter stenosis).Method Three hospitals in Germany recruited participants for this randomised trial between July 2000 and June 2002.
机译：背景技术随着支架使用的增加，支架内再狭窄的发生率也增加。每年，全世界大约进行两百万次经皮干预。临床再狭窄发生率在12％至15％之间，因此每年有240,000至300,000人需要重新进行血管再血管化。在早期的支架试验中，有15％至20％的参与者发生了血管造影再狭窄，但是，随着支架扩大到更复杂的病变和临床组，我们了解到在复杂的病变中血管造影的再狭窄率可以达到30％至50％。糖尿病，参考血管直径小和病变长的人的发病率更高。试验了多种减少再狭窄的技术，包括用磷酰胆碱（PC）涂覆支架。ObjectiveHausleiter及其同事比较了PC涂层支架与经皮腔内冠状动脉成形术（PTCA）对小冠状动脉再狭窄的影响。主要终点为血管造影再狭窄的发生率（直径狭窄大于或等于50％）。方法德国的三家医院于2000年7月至2002年6月之间招募了该随机试验的参与者。

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