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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Sleep deprivation reduces total plasma homocysteine levels in rats.
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Sleep deprivation reduces total plasma homocysteine levels in rats.

机译：睡眠剥夺降低了大鼠的血浆总同型半胱氨酸水平。

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摘要

Hyperhomocysteinemia has been associated with pathological and stressful conditions and is a risk factor for cardiovascular disease. Since sleep deprivation is a stressful condition that is associated with disruption of various physiological processes, we investigated whether it would also be associated with increases in plasma homocysteine levels. Further, since hyperhomocysteinemia may promote oxidative stress, and we had previously found evidence of oxidative stress in brain following sleep deprivation, we also searched for evidence of systemic oxidative stress by measuring glutathione and thiobarbituric acid reactive substance levels. Rats were sleep deprived for 96 h using the platform technique. A group was killed after sleep deprivation and another two groups were allowed to undergo sleep recovery for 24 or 48 h. Contrary to expectation, plasma homocysteine was reduced in sleep-deprived rats as compared with the control group and did not revert to normal levels after 24 or 48 h of sleep recovery. A trend was observed towards decreased glutathione and increased thiobarbituric acid reactive substance levels in sleep-deprived rats. It is possible that the observed decreases in homocysteine levels may represent a self-correcting response to depleted glutathione in sleep-deprived animals, which would contribute to the attenuation of the deleterious effects of sleep deprivation.
机译：高同型半胱氨酸血症已与病理和压力状况有关，是心血管疾病的危险因素。由于睡眠剥夺是一种与各种生理过程中断有关的压力性疾病，因此我们研究了它是否也与血浆同型半胱氨酸水平升高有关。此外，由于高同型半胱氨酸血症可能会促进氧化应激，并且我们先前已经发现睡眠剥夺后大脑中存在氧化应激的证据，因此我们还通过测量谷胱甘肽和硫代巴比妥酸反应性物质的含量来寻找全身氧化应激的证据。使用平台技术将大鼠睡眠剥夺96小时。剥夺睡眠后，将一组杀死，另两组允许睡眠恢复24或48小时。与预期相反，与对照组相比，睡眠剥夺的大鼠血浆高半胱氨酸减少，并且在恢复睡眠24或48小时后未恢复至正常水平。在睡眠不足的大鼠中观察到谷胱甘肽减少和硫代巴比妥酸反应性物质水平增加的趋势。观察到的同型半胱氨酸水平的降低可能代表睡眠不足的动物对耗尽的谷胱甘肽的自我纠正反应，这将有助于减弱睡眠不足的有害作用。

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