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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >The effect of strength training combined with bisphosphonate (etidronate) therapy on bone mineral, lean tissue, and fat mass in postmenopausal women.
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The effect of strength training combined with bisphosphonate (etidronate) therapy on bone mineral, lean tissue, and fat mass in postmenopausal women.

机译：力量训练与双膦酸盐（依替膦酸盐）疗法联合治疗对绝经后妇女的骨矿物质，瘦肉组织和脂肪的影响。

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摘要

The combined and separate effects of exercise training and bisphosphonate (etidronate) therapy on bone mineral in postmenopausal women were compared. Forty-eight postmenopausal women were randomly assigned (double blind) to groups that took intermittent cyclical etidronate; performed strength training (3 d/week) and received matched placebo; combined strength training with etidronate; or took placebo and served as nonexercising controls. Bone mineral, lean tissue, and fat mass were assessed by dual-energy X-ray absorptiometry before and after 12 months of intervention. After removal of outlier results, changes in bone mineral density (BMD) of the lumbar spine and bone mineral content (BMC) of the whole body were greater in the subjects given etidronate (+2.5 and +1.4%, respectively) compared with placebo (-0.32 and 0%, respectively) (p < 0.05), while exercise had no effect. There was no effect of etidronate or exercise on the proximal femur and there was no interaction between exercise and etidronate at any bone site. Exercise training resulted in significantly greater increases in muscular strength and lean tissue mass and greater loss of fat mass compared with controls. We conclude that etidronate significantly increases lumbar spine BMD and whole-body BMC and that strength training has no additional effect. Strength training favourably affects body composition and muscular strength, which may be important for prevention of falls.
机译：比较了运动训练和双膦酸盐（etidronate）治疗对绝经后妇女骨矿物质的联合和单独作用。将四十八名绝经后妇女随机分配（双盲）到间歇性周期性依替膦酸钠组中。进行力量训练（每周3天）并接受匹配的安慰剂;结合力量训练与依替膦酸盐;或服用安慰剂并作为非运动对照。干预前后12个月，通过双能X线骨密度仪评估骨矿物质，瘦肉组织和脂肪量。排除异常结果后，与安慰剂相比，接受依替膦酸盐治疗的受试者腰椎骨矿物质密度（BMD）和全身骨矿物质含量（BMC）的变化更大（分别为+2.5和+1.4％）（ -0.32和0％分别为（p <0.05），而运动没有效果。依替膦酸盐或运动对股骨近端无影响，运动与依替膦酸盐在任何骨部位均无相互作用。与对照组相比，运动训练可显着增加肌肉力量和瘦肉组织的质量，并减少更多的脂肪。我们得出的结论是，依替膦酸显着增加腰椎BMD和全身BMC，并且力量训练没有其他效果。力量训练有利地影响身体成分和肌肉力量，这对于预防跌倒可能很重要。

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