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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Red yeast rice and coenzyme Q(10) as safe alternatives to surmount atorvastatin-induced myopathy in hyperlipidemic rats
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Red yeast rice and coenzyme Q(10) as safe alternatives to surmount atorvastatin-induced myopathy in hyperlipidemic rats

机译：红曲米和辅酶Q（10）作为高脂血症大鼠克服阿托伐他汀诱导的肌病的安全替代品

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Statins are the first line treatment for the management of hyperlipidemia. However, the primary adverse effect limiting their use is myopathy. This study examines the efficacy and safety of red yeast rice (RYR), a source of natural statins, as compared with atorvastatin, which is the most widely used synthetic statin. Statin interference with the endogenous synthesis of coenzyme Q(10) (CoQ(10)) prompted the hypothesis that its deficiency may be implicated in the pathogenesis of statin-associated myopathy. Hence, the effects of combination of CoQ(10) with either statin have been evaluated. Rats were rendered hyperlipidemic through feeding them a high-fat diet for 90 days, during the last 30 days of the diet they were treated daily with either atorvastatin, RYR, CoQ(10), or combined regimens. Lipid profile, liver function tests, and creatine kinase were monitored after 15 and 30 days of drug treatments. Heart contents of CoQ(9) and CoQ(10) were assessed and histopathological examination of the liver and aortic wall was performed. RYR and CoQ(10) had the advantage over atorvastatin in that they lower cholesterol without elevating creatine kinase, a hallmark of myopathy. RYR maintained normal levels of heart ubiquinones, which are essential components for energy production in muscles. In conclusion, RYR and CoQ(10) may offer alternatives to overcome atorvastatin-associated myopathy.
机译：他汀类药物是控制高脂血症的一线治疗。但是，限制其使用的主要不良反应是肌病。这项研究检查了天然酵母素来源的红曲米（RYR）与最广泛使用的合成他汀类药物阿托伐他汀相比的功效和安全性。他汀类药物与辅酶Q（10）（CoQ（10））的内源性合成的干扰提出了一个假设，即其缺乏可能与他汀类药物相关的肌病的发病机制有关。因此，已经评估了CoQ（10）与他汀类药物联合使用的效果。通过高脂饮食喂养大鼠90天，使其处于高血脂状态，在饮食的最后30天内，每天用阿托伐他汀，RYR，CoQ（10）或联合方案治疗大鼠。药物治疗15天和30天后，监测血脂谱，肝功能测试和肌酸激酶。评估了CoQ（9）和CoQ（10）的心脏含量，并对肝脏和主动脉壁进行了组织病理学检查。 RYR和CoQ（10）优于阿托伐他汀，因为它们在不增加肌酸激酶（肌病特征）的情况下降低胆固醇。 RYR维持心脏泛醌的正常水平，这是肌肉产生能量的必要组成部分。总之，RYR和CoQ（10）可能提供克服阿托伐他汀相关肌病的替代方法。

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