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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Camel milk and bee honey regulate profibrotic cytokine gene transcripts in liver cirrhosis induced by carbon tetrachloride
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Camel milk and bee honey regulate profibrotic cytokine gene transcripts in liver cirrhosis induced by carbon tetrachloride

机译：骆驼奶和蜂蜂蜜调节四氯化碳所致肝硬化的纤维化细胞因子基因转录本

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摘要

The lack of studies regarding the mechanism of the protective effects of camel milk and bee honey against hepatotoxic compounds led us to perform this study. Thirty-six male rats were divided into two main groups. The first group (n = 9) comprised control non-cirrhotic rats. The rats of the second group (n = 27) were administered carbon tetrachloride (CCl4) by intraperitoneal injection to induce liver cirrhosis. The cirrhotic rats were then divided into three equal subgroups, each comprising nine animals, as follows: (i) cirrhotic rats, (ii) cirrhotic rats treated with camel milk, and (iii) cirrhotic rats treated with camel milk and bee honey. The present findings revealed that CCl4 elevated the activities of liver enzymes, blood glucose levels, non-esterified fatty acids (NEFA) in the serum and glycogen content in the liver. On the other hand, CCl4 significantly decreased phosphorylase activity in the liver tissue and significantly increased carbohydrate intolerance and insulin resistance index (HOMA-IR). Moreover, CCl4 induced a significant increase in oxidative stress, along with increased expression of the profibrotic cytokine genes TNF-alpha and TGF-beta. However, camel milk either alone or in combination with bee honey ameliorated these toxic actions. The antioxidant properties of these protective agents and their effects of downregulating certain procirrhotic cytokine gene transcripts underlie this protection.
机译：缺乏关于骆驼奶和蜂蜂蜜对肝毒性化合物的保护作用机理的研究使我们进行了这项研究。将36只雄性大鼠分为两个主要组。第一组（n = 9）包括对照组非肝硬化大鼠。第二组（n = 27）的大鼠通过腹腔注射给予四氯化碳（CCl4），以诱发肝硬化。然后将肝硬化大鼠分成三个相等的亚组，每组包括九只动物，如下：（i）肝硬化大鼠，（ii）用骆驼奶治疗的肝硬化大鼠，和（iii）用骆驼奶和蜂蜂蜜治疗的肝硬化大鼠。目前的发现表明，CCl4升高了血清中肝酶的活性，血糖水平，非酯化脂肪酸（NEFA）和肝糖原含量。另一方面，CCl4显着降低了肝组织中的磷酸化酶活性，并显着提高了糖耐量和胰岛素抵抗指数（HOMA-IR）。此外，CCl4引起氧化应激的显着增加，以及纤维化细胞因子基因TNF-α和TGF-β的表达增加。但是，单独或与蜜蜂蜂蜜混合使用的骆驼奶可改善这些毒性作用。这些保护剂的抗氧化特性及其下调某些肝硬化细胞因子基因转录本的作用是这种保护的基础。

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