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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Hepatoprotective effect of trans-Chalcone on experimentally induced hepatic injury in rats: inhibition of hepatic inflammation and fibrosis
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Hepatoprotective effect of trans-Chalcone on experimentally induced hepatic injury in rats: inhibition of hepatic inflammation and fibrosis

机译：反查尔酮对大鼠实验性肝损伤的保肝作用：抑制肝炎症和纤维化

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摘要

The current study investigated the hepatoprotective effect of trans-Chalcone in carbon tetrachloride (CCl4) and paracetamol (PCM) induced liver damage in rats. Administration of CCl4 and PCM (1 mL/kg, i.p., 3 days, and 2 g/kg, p.o., single dose, respectively) produced hepatic injury. Ponderal changes (percent change in body mass and relative liver mass) and biochemical parameters (serum ALT, AST, ALP, bilirubin) were estimated. The markers of oxidative and nitrosative stress (TBARS, reduced GSH, nitrite and nitrate), hepatic fibrosis (TGF-beta 1, collagen content), hepatic inflammation (TNF-alpha), and histopathological study were evaluated. trans-Chalcone (5, 10, and 20 mg/kg, i.p.) was found to be beneficial as demonstrated by significant reversal of liver histology by perceptible reduction of inflammatory cell infiltration with regenerative changes in hepatocytes. Improvement in percent change in body mass and significant reduction in relative liver mass were observed. Marked reduction in serum levels of ALT, AST, ALP, and bilirubin were noted. Decreases in TBARS and nitrites and nitrates and increases in reduced GSH levels were noted. Hepatic fibrosis and inflammation were significantly decreased. The findings indicate a novel hepatoprotective role for trans-Chalcone by improving hepatic injury by possible actions such as anti-oxidant, anti-nitrosative, antifibrotic, and anti-inflammatory. Hence, it can be used as promising hepatoprotective agent.
机译：目前的研究调查了反查尔酮对四氯化碳（CCl4）和对乙酰氨基酚（PCM）诱导的大鼠肝损伤的肝保护作用。分别给予CCl4和PCM（1 mL / kg，腹腔注射3天和2 g / kg，口服，单剂量）会造成肝损伤。估算了足部变化（体重和相对肝脏质量的变化百分比）和生化参数（血清ALT，AST，ALP，胆红素）。评估了氧化和亚硝化应激（TBARS，减少的GSH，亚硝酸盐和硝酸盐），肝纤维化（TGF-β1，胶原蛋白含量），肝炎（TNF-α）和组织病理学研究的标志物。发现反式查尔酮（5、10和20 mg / kg，腹腔注射）是有益的，如通过明显减少炎症细胞浸润和肝细胞的再生改变，明显逆转了肝脏组织学，证明了这一点。观察到体重变化百分比的改善和相对肝脏质量的显着降低。注意到血清ALT，AST，ALP和胆红素水平明显降低。注意到TBARS，亚硝酸盐和硝酸盐的减少以及减少的GSH水平的增加。肝纤维化和炎症明显减少。这些发现表明，通过抗氧化，抗亚硝化，抗纤维化和抗炎等可能的作用来改善肝损伤，对反查尔酮具有新的肝保护作用。因此，它可用作有希望的肝保护剂。

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