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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Different blood pressure responses to opioids in 3 rat hypertension models: role of the baseline status of sympathetic and renin-angiotensin systems
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Different blood pressure responses to opioids in 3 rat hypertension models: role of the baseline status of sympathetic and renin-angiotensin systems

机译：在三种大鼠高血压模型中对阿片类药物的不同血压反应：交感神经系统和肾素-血管紧张素系统的基线状态的作用

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Opioids interact with sympathetic and renin-angiotensin systems in control of mean arterial pressure (MAP). Our earlier finding that biphalin, a synthetic enkephalin analogue, decreased MAP in anaesthetized spontaneously hypertensive rats (SHR) prompted us to further explore this action, to get new insights into pathogenesis of various forms of hypertension. Biphalin effects were studied in SHR, uninephrectomized rats on a high-salt diet (HS/UNX), and rats with angiotensin-induced hypertension (Ang-iH). Besides MAP, renal and iliac blood flows (RBF, IBF) and vascular resistances were measured. In anaesthetized and conscious SHR, biphalin (300 mu g.h(-1).kg(-1) i.v.) decreased MAP by similar to 10 and similar to 20 mm Hg, respectively (P < 0.001). In anaesthetized HS/UNX and normotensive rats, MAP increased by similar to 6-7 mm Hg (P < 0.02); without anaesthesia, only transient decreases occurred. MAP never changed in Ang-iH rats. Morphine (1.5 mg.h(-1).kg(-1) i.v.) decreased MAP in HS/UNX but only transiently so without anaesthesia; such anaesthesia dependence of response was also seen in normotensive rats. Ang-iH rats never responded to morphine. Hypotensive effect in SHR only depends primarily on the reduction by biphalin of vascular responsiveness to increased sympathetic stimulation; such increase is well documented for SHR. No MAP response to biphalin or morphine in Ang-iH could depend on angiotensin-induced alterations of the vascular wall morphology and function.
机译：阿片类药物与交感神经系统和肾素-血管紧张素系统相互作用，以控制平均动脉压（MAP）。我们较早的发现，即合成的脑啡肽类似物Biphalin降低了麻醉的自发性高血压大鼠（SHR）的MAP，促使我们进一步探索这一作用，从而获得了对各种形式高血压的发病机理的新见解。在SHR，高盐饮食（HS / UNX）的未切除子宫的大鼠以及血管紧张素诱导的高血压（Ang-iH）的大鼠中研究了Biphalin的作用。除了MAP，还测量了肾脏和的血流（RBF，IBF）和血管阻力。在麻醉的和有意识的SHR中，biphalin（300μg.h（-1）.kg（-1）i.v.）使MAP分别降低了约10和20 mm Hg（P <0.001）。在麻醉的HS / UNX和血压正常的大鼠中，MAP升高约6-7 mm Hg（P <0.02）;没有麻醉，只有短暂的减少发生。 MAP在Ang-iH大鼠中从未改变。吗啡（1.5 mg.h（-1）.kg（-1）i.v.）降低HS / UNX中的MAP，但只是短暂地降低麻醉效果;在血压正常的大鼠中也观察到了这种麻醉对反应的依赖性。 Ang-iH大鼠从未对吗啡有反应。 SHR的降压作用主要取决于Biphalin降低对交感刺激增强的血管反应性。对于SHR，这种增加已得到充分证明。在Ang-iH中对MAP或吗啡没有MAP反应可能取决于血管紧张素诱导的血管壁形态和功能的改变。

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