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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Inflammatory cytokines and malnutrition as related to risk for cardiovascular disease in hemodialysis patients.
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Inflammatory cytokines and malnutrition as related to risk for cardiovascular disease in hemodialysis patients.

机译：炎性细胞因子和营养不良与血液透析患者心血管疾病的风险有关。

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摘要

Malnutrition and inflammation are associated with end-stage renal disease (ESRD). Interleukin (IL)-6 and tumor necrosis factor alpha (TNF-alpha) powerfully predict death from cardiovascular disease. The aim of our study was to establish an association between markers of inflammation and parameters of malnutrition in patients on hemodialysis. The study population consisted of 42 hemodialysis patients with different parameters of malnutrition. Blood samples were taken after an overnight fast, and plasma lipid profiles (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) were measured by using conventional enzymatic methods. Serum urea and creatinine levels were also measured by routine procedures. Plasma high-sensitivity C-reactive protein level (hs-CRP), TNF-alpha, and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA). Standard Doppler echo examinations were used to determine plaque on carotid arteries, and end-diastolic diameter (EDD) and ejection fraction (EF) were measured by echocardiography. Malnourished patients exhibited significantly greater evidence of cardiovascular disease and carotid plaques. Factor (principal component) analysis indicated 6 latent factors with 67.5% of the variance explained within all investigated parameters. Cluster analysis was used to distinguish the inflammatory markers and the nutritional markers from other parameters and to visualize similarities between variables. In summary, this cross-sectional study in hemodialysis patients found a high prevalence of malnutrition, inflammation, carotid plaques, and cardiovascular disease. Malnourished dialysis patients are more often found with cardiovascular disease and carotid plaques. In addition, these patients have higher levels of inflammatory cytokines, which may partly explain the elevated risk for atherosclerotic vascular disease.
机译：营养不良和炎症与终末期肾脏疾病（ESRD）相关。白介素（IL）-6和肿瘤坏死因子α（TNF-alpha）有力地预测了心血管疾病的死亡。我们研究的目的是建立血液透析患者炎症指标与营养不良参数之间的关联。研究人群包括42名营养不良参数不同的血液透析患者。禁食过夜后采集血样，并使用常规酶促方法测量血浆脂质谱（总胆固醇，LDL胆固醇，HDL胆固醇和甘油三酸酯）。血清尿素和肌酐水平也通过常规程序测量。通过酶联免疫吸附测定（ELISA）测定血浆高敏C反应蛋白水平（hs-CRP），TNF-α和IL-6。使用标准多普勒回声检查确定颈动脉斑块，并通过超声心动图测量舒张末期直径（EDD）和射血分数（EF）。营养不良的患者表现出明显更多的心血管疾病和颈动脉斑块证据。因子（主要成分）分析显示6个潜在因子，在所有调查参数中解释了67.5％的方差。聚类分析用于将炎症标志物和营养标志物与其他参数区分开，并可视化变量之间的相似性。总而言之，这项针对血液透析患者的横断面研究发现营养不良，炎症，颈动脉斑块和心血管疾病的患病率很高。营养不良的透析患者更常患有心血管疾病和颈动脉斑块。此外，这些患者的炎症细胞因子水平较高，这可能部分解释了动脉粥样硬化性血管疾病的风险增加。

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