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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Increased glucose synthesis in renal tubule fragments from hyperthyroid rats.
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Increased glucose synthesis in renal tubule fragments from hyperthyroid rats.

机译：甲状腺功能亢进大鼠肾小管碎片中葡萄糖合成增加。

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摘要

Rates of glucose synthesis from several substrates were examined in renal tubule fragments from hyperthyroid rats. A hyperthyroid state was induced by daily intraperitoneal injections of thyroxine (T4) (100 microg/100 g body weight) for 14 days. At the end of the experimental period, plasma triiodothyronine and T4 levels were six and eight times higher, respectively, than initial values. Hyperthyroid rats gained less weight and had lower blood glucose despite an increased food intake. In both control and hyperthyroid rats, rates of glucose production by renal tubule fragments were higher with glutamine and glycerol than with lactate, alanine, or glutamate. T4 treatment induced a significant increase in the de novo glucose synthesis from all substrates, except glutamine. The highest percent increase was obtained with alanine (64%), compared with 31-40% for glutamate, lactate, and glycerol. The T4 treatment induced increase in glucose synthesis by renal tubule fragments suggests that renal gluconeogenesis contributes to enhance glucose production in hyperthyroidism.
机译：在甲状腺功能亢进大鼠的肾小管碎片中检查了几种底物的葡萄糖合成速率。每天腹腔注射甲状腺素（T4）（100微克/ 100克体重）持续14天，可导致甲亢状态。在实验期结束时，血浆三碘甲状腺素和T4水平分别比初始值高六倍和八倍。尽管食物摄入增加，甲状腺功能亢进的大鼠体重减轻，血糖降低。在对照和甲状腺功能亢进大鼠中，谷氨酰胺和甘油引起的肾小管碎片产生葡萄糖的速率高于乳酸，丙氨酸或谷氨酸。 T4处理导致除谷氨酰胺外所有底物的从头葡萄糖合成显着增加。丙氨酸（64％）的增幅最高，而谷氨酸，乳酸盐和甘油的增幅为31-40％。 T4处理诱导的肾小管碎片引起的葡萄糖合成增加，提示肾糖原异生有助于甲状腺功能亢进症中葡萄糖的产生。

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