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首页> 外文期刊>Gene expression >Expression of alcoholism-relevant genes in the liver are differently correlated to different parts of the brain
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Expression of alcoholism-relevant genes in the liver are differently correlated to different parts of the brain

机译：酒精中毒相关基因在肝脏中的表达与大脑的不同部位有不同的相关性

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The purpose of this study is to investigate whether expression profiles of alcoholism-relevant genes in different parts of the brain are correlated differently with those in the liver. Four experiments were conducted. First, we used gene expression profiles from five parts of the brain (striatum, prefrontal cortex, nucleus accumbens, hippocampus, and cerebellum) and from liver in a population of recombinant inbred mouse strains to examine the expression association of 10 alcoholism-relevant genes. Second, we conducted the same association analysis between brain structures and the lung. Third, using five randomly selected, nonalcoholism-relevant genes, we conducted the association analysis between brain and liver. Finally, we compared the expression of 10 alcoholism-relevant genes in hippocampus and cerebellum between an alcohol preference strain and a wild-type control. We observed a difference in correlation patterns in expression levels of 10 alcoholismrelevant genes between different parts of the brain with those of liver. We then examined the association of gene expression between alcohol dehydrogenases (Adh1, Adh2, Adh5, and Adh7) and different parts of the brain. The results were similar to those of the 10 genes. Then, we found that the association of those genes between brain structures and lung was different from that of liver. Next, we found that the association patterns of five alcoholism-nonrelevant genes were different from those of 10 alcoholism-relevant genes. Finally, we found that the expression level of 10 alcohol-relevant genes is influenced more in hippocampus than in cerebellum in the alcohol preference strain. Our results show that the expression of alcoholism-relevant genes in liver is differently associated with the expression of genes in different parts of the brain. Because different structural changes in different parts of the brain in alcoholism have been reported, it is important to investigate whether those structural differences in the brains of those with alcoholism are due to the difference in the associations of gene expression between genes in liver and in different parts of the brain.
机译：这项研究的目的是调查与酒精中毒相关的基因在大脑不同部位的表达谱是否与肝脏中的相关。进行了四个实验。首先，我们在重组近交系小鼠品系中使用了来自大脑五个部位（纹状体，前额叶皮层，伏隔核，海马和小脑）和肝脏的基因表达谱，以检查10种与酒精中毒相关的基因的表达关联。其次，我们在大脑结构和肺之间进行了相同的关联分析。第三，我们使用五个随机选择的，与酒精中毒无关的基因，进行了大脑和肝脏之间的关联分析。最后，我们比较了酒精偏爱菌株和野生型对照在海马和小脑中10种与酒精中毒相关的基因的表达。我们观察到在大脑的不同部分与肝脏的10个与酒精中毒相关的基因的表达水平的相关模式上存在差异。然后，我们检查了酒精脱氢酶（Adh1，Adh2，Adh5和Adh7）与大脑不同部位之间的基因表达关联。结果与10个基因的结果相似。然后，我们发现这些基因在大脑结构和肺之间的关联与肝脏之间的关联不同。接下来，我们发现5个与酒精中毒无关的基因与10个与酒精中毒无关的基因的关联模式不同。最后，我们发现在酒精偏好菌株中，与酒精相关的10个与酒精相关的基因的表达水平比在小脑中受到的影响更大。我们的研究结果表明，酒精中毒相关基因在肝脏中的表达与大脑不同部位的基因表达不同。由于已经报道了酒精中毒时大脑不同部位的结构发生了变化，因此研究酒精中毒者的大脑中的结构差异是否是由于肝脏内和不同基因之间的基因表达关联不同而引起的，这一点很重要。大脑的一部分。

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