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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Bovine lactoferrin protects lipopolysaccharide-induced diarrhea modulating nitric oxide and prostaglandin E2 in mice.
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Bovine lactoferrin protects lipopolysaccharide-induced diarrhea modulating nitric oxide and prostaglandin E2 in mice.

机译：牛乳铁蛋白可保护脂多糖诱导的腹泻，调节小鼠的一氧化氮和前列腺素E2。

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摘要

Lactoferrin (Lf), an iron-binding multifunctional glycoprotein, is abundantly present in colostrum and milk of different species such as humans, bovines, and mice. Our previous observation revealed that bovine colostral Lf is transported into the systemic circulation and cerebrospinal fluid from gut-lumen through receptor-mediated transcytosis in calves. Diarrhea caused by Escherichia coli is one of the important causes of infant morbidity and mortality in developing countries. We investigated the effects of bovine lactoferrin (BLf) on lipopolysaccharide (LPS)-induced diarrheogenic activity, gastrointestinal transit (GIT), and intestinal fluid content in mice. LPS accumulated abundant fluid in the small intestine in a dose-dependent manner, induced diarrhea, but decreased the GIT. Pretreatment with BLf significantly attenuated the effects of LPS on the diarrheogenic activity and intestinal content, but reversed the GIT when compared with NG-nitro-L-arginine-methyl ester (L-NAME, a non-selective NOS inhibitor) or indomethacin (an inhibitor of prostaglandin synthesis). Both plasma NO and PGE2 in enterocytes were found to increase in LPS-treated mice and were reversed by BLf. These findings demonstrate that the action of BLf against LPS was specific and it exerts antidiarrheal activity through modulating the cyclooxygenase [NO and PGE2] pathway in the gut.
机译：乳铁蛋白（Lf）是一种与铁结合的多功能糖蛋白，广泛存在于人类，牛和小鼠等不同物种的初乳和牛奶中。我们以前的观察结果表明，牛初乳Lf通过受体介导的小牛转运从肠腔进入体循环和脑脊液。大肠杆菌引起的腹泻是发展中国家婴儿发病和死亡的重要原因之一。我们调查了牛乳铁蛋白（BLf）对脂多糖（LPS）诱导的腹泻活性，胃肠道转运（GIT）和小鼠肠液含量的影响。 LPS以剂量依赖性方式在小肠中积聚大量液体，引起腹泻，但降低了GIT。与NG-硝基-L-精氨酸甲酯（L-NAME，一种非选择性的NOS抑制剂）或消炎痛（一种前列腺素合成抑制剂）。发现在经LPS处理的小鼠中肠细胞中的血浆NO和PGE2均升高，并被BLf逆转。这些发现表明，BLf对LPS的作用是特异性的，并且它通过调节肠道中的环氧合酶[NO和PGE2]途径发挥了止泻作用。

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