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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Transforming growth factor-beta (TGF-beta) activation in cutaneous wounds after topical application of aloe vera gel
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Transforming growth factor-beta (TGF-beta) activation in cutaneous wounds after topical application of aloe vera gel

机译：局部应用芦荟凝胶后皮肤伤口中的转化生长因子-β（TGF-β）活化

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摘要

Aloe vera is a medicinal plant used to treat various skin diseases. The effects of using aloe vera gel on the healing process were investigated by microscopic methods, cell counting, and TGF-beta gene expression in the wound bed. Sixty Wistar rats weighing 200-250 g were placed under anesthesia in sterile conditions. A square 1.5 cm x 1.5 cm wound was made on the back of the neck. The rats were divided into control and 2 experimental groups. Additionally, the control and experimental groups were separated into 3 subgroups corresponding to 4, 7, and 14 days of study. In the first experimental group, aloe vera was used twice on the wound. The second experimental group received aloe vera overtreatment once on the wound. The positive control group received daily application of 1% phenytoein cream following surgical wound creation. The control group did not receive any treatment. This tissue was examined using histological staining (H&E) and Masson's Trichrome. Wound surface and wound healing were evaluated separately. TGF-beta gene expression was analyzed by RT-PCR. Results showed that fibroblasts in both experimental groups were significantly increased, thereby acceleration wound healing. Application of aloe vera gel will increase TGF-beta gene expression, ultimately accelerating the wound healing process.
机译：芦荟是用于治疗各种皮肤疾病的药用植物。通过显微镜方法，细胞计数和创面床中的TGF-β基因表达研究了芦荟凝胶对愈合过程的影响。将六十只体重为200-250 g的Wistar大鼠置于无菌条件下麻醉。在脖子的背面打一个1.5厘米x 1.5厘米的正方形伤口。将大鼠分为对照组和2个实验组。此外，将对照组和实验组分为3个亚组，分别对应于研究的4、7和14天。在第一个实验组中，芦荟在伤口上使用了两次。第二实验组在伤口上接受了芦荟过度治疗。阳性对照组在创面手术后每天接受1％的苯妥英乳膏。对照组未接受任何治疗。使用组织学染色（H＆E）和Masson's Trichrome检查该组织。分别评估伤口表面和伤口愈合情况。通过RT-PCR分析TGF-β基因表达。结果表明，两个实验组的成纤维细胞均显着增加，从而加速了伤口的愈合。芦荟凝胶的应用将增加TGF-β基因的表达，最终加速伤口愈合过程。

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