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首页> 外文期刊>Fish & Shellfish Immunology >Can immunostimulants efficiently replace antibiotic in striped catfish (Pangasianodon hypophthalmus) against bacterial infection by Edwardsiella ictaluri?
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Can immunostimulants efficiently replace antibiotic in striped catfish (Pangasianodon hypophthalmus) against bacterial infection by Edwardsiella ictaluri?

机译：免疫刺激剂能否有效替代条纹cat鱼（Pangasianodon hypophthalmus）中的抗生素，以防止由爱德华氏菌引起的细菌感染？

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The present study was performed to determine the efficacy of lipopolysaccharide (LPS) and levamisole on immune response and disease resistance in striped catfish and to compare their respective efficiency with the one of an antibiotic treatment after infection of fish by the bacteria Edwardsiella ictaluri. Fish were divided into 3 groups and each group was injected with LPS (3 mg/kg fish), levamisole (5 mg/kg fish) or phosphate buffer saline as control. At day 21st post immunostimulant injection, fish were bled for assaying immunological variables and then challenged with E. ictaluri. Three days after bacterial infection, an antibiotic treatment was applied into fish subgroups and mortality was compared daily between antibiotic treated and untreated fish until 2 weeks post-challenge. LPS and levamisole significantly enhanced non-specific immune responses such as respiratory burst, lysozyme and complement activity in fish compared with control (p 0.05). Respiratory burst and complement activity significantly increased in levamisole groups when compared with LPS groups while lysozyme activity did not differ significantly between immunostimulant treatments. Total immunoglobulins significantly increased in levamisole treatment compared with control. After challenge test, accumulated mortality was reduced significantly in both non-antibiotic and antibiotic subgroups of LPS and levamisole compared with control. Moreover, no differences of mortality were observed between fish treated with levamisole or LPS without antibiotics and control fish treated with antibiotics. These results support the possible replacement of antibiotics in striped catfish farming by immunostimulants such as levamisole and LPS
机译：进行本研究是为了确定脂多糖（LPS）和左旋咪唑对条纹immune鱼的免疫反应和抗病性的功效，并将它们各自的功效与爱德华氏菌感染鱼后的抗生素治疗方法之一进行比较。将鱼分为3组，每组注射LPS（3 mg / kg鱼），左旋咪唑（5 mg / kg鱼）或磷酸盐缓冲液作为对照。免疫刺激剂注射后第21天，给鱼放血以测定免疫学变量，然后用ic肠埃希菌攻击。细菌感染后三天，对鱼类亚组进行抗生素治疗，每天比较抗生素治疗和未经治疗的鱼类的死亡率，直至攻击后2周。与对照组相比，LPS和左旋咪唑显着增强了鱼类的非特异性免疫反应，如呼吸爆发，溶菌酶和补体活性（p <0.05）。与LPS组相比，左旋咪唑组的呼吸爆发和补体活性显着增加，而免疫刺激治疗之间的溶菌酶活性没有显着差异。与对照相比，左旋咪唑治疗的总免疫球蛋白显着增加。激发试验后，与对照组相比，LPS和左旋咪唑的非抗生素和抗生素亚组的累积死亡率显着降低。此外，在未使用抗生素的左旋咪唑或LPS处理的鱼与使用抗生素处理的对照鱼之间，未观察到死亡率差异。这些结果支持用免疫刺激剂如左旋咪唑和LPS替代striped鱼养殖中的抗生素

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