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首页> 外文期刊>Fish & Shellfish Immunology >Enhancement of non-specific immune response in sea cucumber (Apostichopus japonicus) by Astragalus membranaceus and its polysaccharides
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Enhancement of non-specific immune response in sea cucumber (Apostichopus japonicus) by Astragalus membranaceus and its polysaccharides

机译：黄芪及其多糖对海参非特异性免疫反应的增强作用

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摘要

In this study, the immunostimulatory effect of oral administration of different preparations (conventional fine powder [CP] and superfine powder [SP]) of Astragalus membranaceus root or its polysaccharides (APS) in sea cucumber (Apostichopus japonicus) was investigated. Sea cucumbers with an average initial weight of 49.3 +/- 5.65 g were fed with a diet containing 3% CP or SP or 0.3% APS over a period of 60 days. The non-specific humoral (phenoloxidase, lysozyme and agglutination titer) and cellular (phagocytic capacity and reactive oxygen species) responses were determined and compared with controls (no supplement) after 20, 40 and 60 days of feeding. Variation in the levels of responses was evident among different supplements. SP and APS significantly enhanced most of the immune parameters tested. Among the humoral responses, lysozyme activity significantly increased after feeding with SP-supplemented diet for 20, 40 or 60 days. Furthermore, lectin titer showed significant enhancement after 20 and 60 days of feeding with APS-supplemented diet. Significant increase in the production of reactive oxygen species was evident for all three supplements after 20 days of feeding, but no significant change in serum phenoloxidase activity was observed for any of the three supplements over the three different periods. Overall, significant modulation of the cellular responses was only noticed after 20 days of feeding with SP- or APS-supplemented diet. After 60 days, these two groups also exhibited a decrease in the cumulative symptom rates compared to the controls when challenged with Vibrio splendidus. These results indicated that dietary intake containing A. membranaceus root or its polysaccharides could enhance the immune responses of A. japonicus and improve its resistance to infection by V. splendidus.
机译：在这项研究中，研究了海参（Apostichopus japonicus）口服黄芪不同制剂（常规细粉[CP]和超细粉[SP]）或其多糖（APS）的免疫刺激作用。在60天内，将平均初始重量为49.3 +/- 5.65克的海参饲喂含有3％CP或SP或0.3％APS的饲料。测定非特异性体液（酚氧化酶，溶菌酶和凝集滴度）和细胞（吞噬能力和活性氧种类）的反应，并在喂食20、40和60天后与对照（不补充）进行比较。不同补充品之间反应水平的差异很明显。 SP和APS显着增强了大多数测试的免疫参数。在体液反应中，以补充SP的饮​​食喂养20天，40天或60天后，溶菌酶活性显着增加。此外，用补充APS的饲料喂养20天和60天后，凝集素滴度显示出显着提高。喂食20天后，所有三种补品的活性氧种类的产生均明显增加，但在三个不同的时期内，三种补品中的任何一种均未观察到血清酚氧化酶活性的显着变化。总体而言，仅在补充SP或APS的饮食喂养20天后才注意到细胞反应的显着调节。 60天后，当用脾炎弧菌攻击时，与对照组相比，这两组的症状累积率也降低了。这些结果表明，饮食中含有膜曲霉根或其多糖可以增强日本曲霉的免疫反应，并提高其对细小弧菌感染的抵抗力。

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