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首页> 外文期刊>Fish & Shellfish Immunology >Dietary supplementation of Pediococcus pentosaceus enhances innate immunity, physiological health and resistance to Vibrio anguillarum in orange-spotted grouper (Epinephelus coioides)
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Dietary supplementation of Pediococcus pentosaceus enhances innate immunity, physiological health and resistance to Vibrio anguillarum in orange-spotted grouper (Epinephelus coioides)

机译：膳食补充戊糖戊球菌可增强橙斑石斑鱼（石斑鱼）的先天免疫力，生理健康和对鳗弧菌的抵抗力。

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摘要

Groupers (Epinephelus spp.) are economically important fish species in Southeast Asian aquaculture. Vibriosis caused by Vibro spp. is one of the severe bacterial diseases that devastate the grouper aquaculture industry. Probiotics have been reported to show the potential to enhance fish immunity and to antagonize pathogens. In our previous study, a lactic acid bacterium Pediococcus pentosaceus strain 4012 (LAB4012), isolated from cobia intestine, protects cobia from photobacteriosis after a 2-week feeding. In this study, we examined the potential of LAB4012 to be a probiotic for the orange-spotted grouper through feeding, thus to guard against vibriosis. In vitro, LAB4012 culture supernatant with low pH suppressed the growth of Vibrio anguillarum, and lactic acid in the metabolite of LAB4012 appeared to be the major factor to the growth inhibition of V. anguillarum. In vivo, the challenge test showed that the cumulative mortality of the LAB4012-fed groupers was significantly lower than that of the control fish after V. anguillarum infection. Supplementation of LAB4012 in commercial diet not only enhanced the growth rate and erythrocyte numbers of the groupers, but also regulated the gene expression of the pro-/anti-inflammatory cytokines. One day post-infection of V. anguillarum, the leukocyte numbers in the peripheral blood and the phagocytic activity of the head-kidney phagocytes in the LAB4012-fed groupers were found significantly increased, when compared with those without LAB4012-feeding. These results suggested that LAB4012 can be a dietary probiotic for groupers in modulating the immunity and protecting the groupers from V. anguiliarum infection
机译：石斑鱼（Epinephelus spp。）是东南亚水产养殖中经济上重要的鱼类。由弧菌引起的弧菌病。是破坏石斑鱼养殖业的严重细菌疾病之一。据报道益生菌显示出增强鱼类免疫力和拮抗病原体的潜力。在我们先前的研究中，从军曹鱼肠中分离出的乳酸细菌戊糖片球菌4012菌株（LAB4012）在喂食2周后可保护军曹鱼免于细菌感染。在这项研究中，我们检查了LAB4012通过饲喂成为橙色斑斑石斑鱼益生菌的潜力，从而预防了弧菌病。在体外，低pH的LAB4012培养上清抑制了鳗弧菌的生长，而LAB4012代谢产物中的乳酸似乎是抑制鳗弧菌生长的主要因素。在体内，攻击试验表明，喂食LAB4012的石斑鱼的累积死亡率显着低于对照鱼，其感染了安圭拉弧菌。在商业饮食中添加LAB4012，不仅可以提高石斑鱼的生长速度和红细胞数量，而且还可以调节促炎/抗炎细胞因子的基因表达。与不使用LAB4012喂养的石斑鱼相比，感染鳗鱼后一天，与饲喂LAB4012的石斑鱼相比，外周血白细胞数和头肾吞噬细胞的吞噬活性显着增加。这些结果表明，LAB4012可以作为石斑鱼的饮食益生菌，可调节免疫力并保护石斑鱼免受鳗弧菌感染。

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