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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Epileptic seizure-induced hypertension and its prevention by calcium channel blockers: a real-time study in conscious telemetered rats.
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Epileptic seizure-induced hypertension and its prevention by calcium channel blockers: a real-time study in conscious telemetered rats.

机译：癫痫性癫痫诱发的高血压及其钙通道阻滞剂的预防：对有意识遥测大鼠的实时研究。

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摘要

Epileptic seizures are accompanied by changes in autonomic function that in turn influence the cardiovascular system (hypertension and bradyarrhythmia). We have studied possible cardioprotective activity (during the ictal state in conscious animals) of valproic acid, nifedipine, and verapamil, alone and in combination, during pentylenetetrazole (PTZ)-induced seizures. Telemetry system was used for recording EEG, blood pressure, and heart rate in conscious, freely moving rats during seizures. We observed that PTZ-induced seizures were accompanied by hypertension and bradyarrhythmia. Pretreatment with valproic acid did not block seizure-induced hypertension and bradyarrhythmia. Nifedipine alone and in combination with valproic acid blocked seizure-induced hypertension and bradyarrhythmia significantly. We also observed that pretreatment with verapamil alone and in combination with valproic acid did not block seizure-induced hypertension and bradyarrhythmia significantly. Our results suggest that pretreatment with nifedipine alone or in combination with valproic acid provides protection against seizure-induced hypertension and bradyarrhythmia.
机译：癫痫发作伴有自主功能的改变，继而影响心血管系统（高血压和心律失常）。我们已经研究了戊戊酸，硝苯地平和维拉帕米在戊烯四唑（PTZ）诱发的癫痫发作中可能的心脏保护活性（在有意识的动物处于发作状态期间），可能单独使用或联合使用。遥测系统用于记录癫痫发作期间有意识，自由运动的大鼠的脑电图，血压和心率。我们观察到，PTZ诱发的癫痫发作伴有高血压和缓慢性心律失常。丙戊酸预处理不能阻止癫痫发作引起的高血压和心律失常。单独使用硝苯地平并与丙戊酸合用可显着阻断癫痫发作引起的高血压和心律失常。我们还观察到单独用维拉帕米和丙戊酸联合预处理并不能显着阻止癫痫发作引起的高血压和心律失常。我们的结果表明，单独使用硝苯地平或与丙戊酸联用进行预处理可预防癫痫发作引起的高血压和心律失常。

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