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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Treatment with nebivolol combined with physical training promotes improvements in the cardiovascular responses of hypertensive rats
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Treatment with nebivolol combined with physical training promotes improvements in the cardiovascular responses of hypertensive rats

机译：奈必洛尔结合体育锻炼的治疗可改善高血压大鼠的心血管反应

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The aim of this study was to determine whether exercise training combined with beta-blocker treatment promotes additional cardiovascular benefits compared with either intervention on its own. For this we used 76 Wistar rats distributed among different groups: normotensive sedentary (NS), normotensive trained (NT), normotensive sedentary treated with betablocker (NS_BB), normotensive trained treated with beta-blocker (NT_BB), hypertensive sedentary (HS), hypertensive trained (HT), hypertensive sedentary treated with a beta-blocker (HS_BB), and hypertensive trained rats treated with beta-blocker (HT_BB). Exercise training consisted of 4 weeks of swimming for 60 min a day, 5 days a week. Hypertension was induced with L-NAME (4 weeks), whereas the control rats received saline, and both the control and test rats received nebivolol. The animals underwent surgery to directly record their blood pressure. The HS group showed higher mean arterial pressure (MAP) (P = 0.000), systolic arterial pressure (P = 0.000), and diastolic arterial pressure (P = 0.000) compared with NS. MAP was higher in the HS compared with the HT (P = 0.002), HS_BB (P = 0.018), and HT_BB (P = 0.015) groups. Hearts from the HS group had a higher percentage of collagen compared with the NS and HS_BB groups. The HT_BB and HT groups only had a higher percentage of cardiac collagen by comparison with the HS_BB group. The HT_BB group showed higher levels of macrophages and neutrophils by comparison with the HT and HS_BB groups. Thus, treatment with a beta-blocker combined with physical training was associated with increased cardiovascular benefits over either intervention alone.
机译：这项研究的目的是确定与单独使用任何一种干预措施相比，运动训练与β受体阻滞剂治疗相结合是否能促进心血管的其他益处。为此，我们使用了76只Wistar大鼠，这些大鼠分布在不同的组中：血压正常的久坐（NS），血压正常的久坐（NT），接受β受体阻滞剂治疗的血压正常久坐（NS_BB），接受β受体阻滞剂治疗的血压正常久坐（NT_BB），高血压的久坐（HS），高血压训练（HT），久坐久经β受体阻滞剂（HS_BB）和高血压训练过的大鼠经β受体阻滞剂（HT_BB）。运动训练包括每周5天，每天60分钟的4周游泳。用L-NAME诱发高血压（4周），而对照组大鼠接受生理盐水，对照组和试验大鼠均接受奈必洛尔。对这些动物进行手术以直接记录其血压。与NS组相比，HS组的平均动脉压（MAP）（P = 0.000），收缩压（P = 0.000）和舒张压（P = 0.000）更高。与HT（P = 0.002），HS_BB（P = 0.018）和HT_BB（P = 0.015）组相比，HS中的MAP更高。与NS和HS_BB组相比，HS组的心脏胶原蛋白百分比更高。与HS_BB组相比，HT_BB和HT组仅具有较高的心脏胶原蛋白百分比。与HT和HS_BB组相比，HT_BB组显示出更高水平的巨噬细胞和中性粒细胞。因此，与任何一种干预措施相比，将β受体阻滞剂与体育锻炼相结合可增加心血管益处。

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