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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Phenytoin and sodium valproate but not levetiracetam induce bone alterations in female mice
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Phenytoin and sodium valproate but not levetiracetam induce bone alterations in female mice

机译：苯妥英钠和丙戊酸钠而不是左乙拉西坦可诱发雌性小鼠的骨质改变

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摘要

Adverse effects on the bone are amongst the potentially adverse clinical consequences with antiepileptic drugs (AEDs). This study compared the effects of 3 AEDs (phenytoin (PHT), sodium valproate (SVP), and levetiracetam (LTM)) on the bones of a Swiss strain of albino female mice. Drugs were administered daily for 4 months at doses that produced plasma concentrations corresponding to the clinically relevant therapeutic ranges. PHT and SVP (but not LTM) significantly lowered the bone mineral density (BMD) of lumbar vertebrae (L2-L4) as evaluated by dual-energy X-ray absorptiometry (DEXA) scan. The findings were supported by histopathology of vertebral (lumbar) bone and analysis of bone turnover markers. While both PHT and SVP reduced alkaline phosphatase (ALP) and hydroxyproline (HxP) in lumbar vertebrae, and elevated tartarate-resistant acid phosphatase (TRAP) and urinary excretion of calcium, LTM did not affect any of these markers of bone turnover, indicating that the drug might be a safer option in female epileptic patients prone to bone changes.
机译：抗癫痫药（AED）对骨骼的不良影响是可能产生的不良临床后果。这项研究比较了3种AED（苯妥英钠（PHT），丙戊酸钠（SVP）和左乙拉西坦（LTM））对瑞士白化病雌性小鼠骨骼的影响。每天以产生血浆​​浓度对应于临床相关治疗范围的剂量给药药物，持续4个月。通过双能X射线吸收法（DEXA）扫描评估，PHT和SVP（而非LTM）显着降低了腰椎（L2-L4）的骨矿物质密度（BMD）。椎骨（腰椎）的组织病理学和骨转换标志物的分析支持了这一发现。虽然PHT和SVP均可降低腰椎中的碱性磷酸酶（ALP）和羟脯氨酸（HxP），并提高抗酒石酸的酸性磷酸酶（TRAP）和尿中钙的排泄，但LTM不会影响这些骨代谢指标。对于容易发生骨质改变的女性癫痫患者，该药物可能是更安全的选择。

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