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首页> 外文期刊>Fish & Shellfish Immunology >Single-walled carbon nanotubes as delivery vehicles enhance the immunoprotective effects of a recombinant vaccine against Aeromonas hydrophila
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Single-walled carbon nanotubes as delivery vehicles enhance the immunoprotective effects of a recombinant vaccine against Aeromonas hydrophila

机译：单壁碳纳米管作为运载工具增强了针对亲水嗜水气单胞菌的重组疫苗的免疫保护作用

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摘要

To reduce the economic losses caused by diseases in aquaculture industry, more efficient and economic prophylactic measures should be urgently investigated. In this research, the effects of a novel functionalized single-walled carbon nanotubes (SWCNTs) applied as a delivery vehicle for recombinant Aeromonas hydrophila vaccine administration via bath or injection in juvenile grass carp were studied. The results showed that SWCNT as a vector for the recombinant protein aerA, augmented the production of specific antibodies, apparently stimulated the induction of immune-related genes, and induced higher level of survival rate compared with free aerA subunit vaccine. Furthermore, we compared the routes of bath and intramuscular injection immunization by SWCNTs-aerA vaccine, and found that similar antibody levels induced by SWCNTs-aerA were observed in both immunization routes. Meanwhile, a similar relative percentage survival (approximately 80%) was found in both a 40 mg/L bath immunization group, and a 20 mu g injection group. The results indicate that functionalized SWCNTs could be a promising delivery vehicle to potentiate the immune response of recombinant vaccines, and might be used to vaccinate juvenile fish by bath administration method. (C) 2014 Elsevier Ltd. All rights reserved.
机译：为了减少水产养殖业中疾病引起的经济损失，应紧急研究更有效和经济的预防措施。在这项研究中，研究了一种新颖的功能化单壁碳纳米管（SWCNTs）的作用，该载体通过在草鱼中洗澡或注射而用于重组嗜水气单胞菌疫苗的给药。结果表明，与游离aerA亚单位疫苗相比，SWCNT作为重组蛋白aerA的载体，增加了特异性抗体的产生，明显刺激了免疫相关基因的诱导，并诱导了更高的存活率。此外，我们比较了SWCNTs-aerA疫苗的沐浴和肌肉注射免疫途径，发现在两种免疫途径中都观察到了相似的SWCNTs-aerA抗体水平。同时，在40 mg / L浴液免疫组和20μg注射组中都发现了相似的相对存活百分率（大约80％）。结果表明功能化的SWCNTs可能是增强重组疫苗免疫反应的有前途的运载工具，并可能通过浴法用于幼鱼的疫苗接种。 （C）2014 Elsevier Ltd.保留所有权利。

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