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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Plasma osmolality and the strong ion difference predict respiratory adaptations in pregnant and nonpregnant women.
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Plasma osmolality and the strong ion difference predict respiratory adaptations in pregnant and nonpregnant women.

机译：血浆渗透压和强烈的离子差异可预测孕妇和非孕妇的呼吸适应。

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摘要

This study tested the hypothesis that plasma osmolality and the strong ion difference ([SID]) predict PaCO2 during rest and during exercise in physically active pregnant (n = 22; gestational age 37.0 +/- 0.2 weeks) and nonpregnant (n = 17) women. Nonpregnant subjects were in varying stages of the menstrual cycle. Arterialized blood gases, hydrogen ion concentration, plasma osmolality, [SID], and circulating levels of progesterone were measured at rest and during upright cycling at work rates corresponding to 70 and 110% of the ventilatory threshold. Pooled data from the two groups at rest revealed significant correlations (P < 0.05) between PaCO2 with plasma osmolality, [SID], and progesterone. Progesterone was also significantly correlated with [SID] and osmolality. Also, changes in PaCO2 with exercise correlated significantly with changes in [SID]. The results support the hypothesis that plasma osmolality and [SID] are important factors in the modulation of respiratory sensitivity in healthy women. Also, the effects of progesterone on PaCO2 may be expressed, at least in part, through progesterone-induced changes in [SID] and osmolality.
机译：这项研究检验了以下假设：在体育活动活跃的孕妇（n = 22;胎龄37.0 +/- 0.2周）和未怀孕（n = 17）中，血浆渗透压和强离子差异（[SID]）预测休息和运动期间的PaCO2。女人。未怀孕的受试者处于月经周期的不同阶段。在静止和直立骑行期间，以对应于通气阈值的70％和110％的工作速率，测量动脉血气，氢离子浓度，血浆渗透压，[SID]和孕酮的循环水平。两组静止的汇总数据显示，PaCO2与血浆渗透压，[SID]和孕酮之间存在显着相关性（P <0.05）。孕酮也与[SID]和渗透压显着相关。此外，运动引起的PaCO2变化与[SID]的变化显着相关。结果支持以下假设：血浆渗透压和[SID]是调节健康女性呼吸敏感性的重要因素。另外，孕酮对PaCO 2的作用可以至少部分地通过孕酮诱导的[SID]和重量克分子渗透压浓度的变化来表达。

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