...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Selected plant species from the Cree pharmacopoeia of northern Quebec possess anti-diabetic potential.
【24h】

Selected plant species from the Cree pharmacopoeia of northern Quebec possess anti-diabetic potential.

机译：从魁北克北部的Cree药典中选择的植物具有抗糖尿病的潜力。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Type II diabetes is a major health problem worldwide. Some populations, such as aboriginal peoples, are particularly at risk for this disease. In the Cree Nation of Quebec, Canada, prevalence in adults is approaching 20%, and the consequences are compounded by low compliance with modern medicine. In 2003, we conducted an ethnobotanical study of Cree medicinal plants used for the treatment of symptoms of diabetes. This served as the basis for a project designed to identify efficacious complementary treatment options more readily accepted by this population. The present study assesses the in vitro anti-diabetic potential of extracts from the 8 most promising plants to emerge from the ethnobotanical study. Cell-based bioassays were employed to screen for (i) potentiation of glucose uptake by skeletal muscle cells (C2C12) and adipocytes (3T3-L1); (ii) potentiation of glucose-stimulated insulin secretion (GSIS) and insulin production by pancreatic beta cells (INS 832/13); (iii) potentiation of triglyceride accumulation in differentiating 3T3-L1 cells; (iv) protection against glucose toxicity and glucose deprivation in pre-sympathetic neurons (PC12-AC). Additionally, anti-oxidant activity was measured biochemically by the diphenylpicrylhydrazyl (DPPH) reduction assay. All plant extracts potentiated basal or insulin-stimulated glucose uptake to some degree in muscle cells or adipocytes. Adipocyte differentiation was accelerated by 4 extracts. Five extracts conferred protection in PC12 cells. Three extracts displayed free radical scavenging activity similar to known anti-oxidants. None of the plant extracts enhanced GSIS or insulin content in INS 832/13 beta cells. It is concluded that the Cree pharmacopoeia contains several plants with significant anti-diabetic potential.
机译：II型糖尿病是全球主要的健康问题。一些人口，例如原住民，特别容易患上这种疾病。在加拿大魁北克的Cree Nation，成年人的患病率接近20％，而对现代医学的依从性低则使后果更加复杂。 2003年，我们进行了Cree药用植物用于糖尿病症状治疗的民族植物学研究。这是旨在确定该人群更容易接受的有效补充治疗方案的项目的基础。本研究评估了来自民族植物学研究的8种最有希望的植物提取物的体外抗糖尿病潜力。基于细胞的生物测定法用于筛选（i）骨骼肌细胞（C2C12）和脂肪细胞（3T3-L1）的葡萄糖摄取增强; （ii）胰腺β细胞增强葡萄糖刺激的胰岛素分泌（GSIS）和胰岛素产生（INS 832/13）; （iii）增强分化的3T3-L1细胞中甘油三酸酯的积累; （iv）预防交感神经元（PC12-AC）中的葡萄糖毒性和葡萄糖剥夺。另外，通过二苯基吡咯并肼基（DPPH）还原测定法以生化方式测量了抗氧化活性。所有植物在肌肉细胞或脂肪细胞中都会提取一定程度的增强的基础或胰岛素刺激的葡萄糖摄取。 4种提取物可促进脂肪细胞分化。五种提取物赋予PC12细胞以保护作用。三种提取物表现出的自由基清除活性类似于已知的抗氧化剂。没有一种植物提取物能提高INS 832/13 beta细胞中GSIS或胰岛素的含量。结论是Cree药典包含几种具有显着抗糖尿病潜力的植物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号