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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Gender differences in the cardiac response to dietary conjugated linoleic acid isomers.
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Gender differences in the cardiac response to dietary conjugated linoleic acid isomers.

机译：对膳食共轭亚油酸异构体心脏反应的性别差异。

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摘要

The present study was undertaken to assess the heart function, by the in vivo catheterization technique, of healthy male and female Sprague-Dawley rats fed different conjugated linoleic acid (CLA) isomers, (cis-9, trans-11 (c9,t11) and trans-10, cis-12 (t10,c12)) individually and in combination (50:50 mix as triglyceride or fatty acids) from 4 to 20 weeks of age. Whereas the triglyceride form of the CLA isomer mix lowered the heart rate, the rate of contraction (+dP/dt) and rate of relaxation (-dP/dt), systolic and diastolic pressures, mean arterial pressure, and the left ventricular systolic pressure were higher in male rats as compared with all the other dietary groups. In contrast, there were no significant effects in the cardiac function of the female rats in response to the CLA isomer mix in triglyceride form. Whereas the heart rate, +dP/dt, and left ventricular systolic pressure were lower in male rats fed the t10,c12 CLA isomer alone, the heart rate of the female rats was higher, but the systolic pressure, +dP/dt, and mean arterial pressure were lower compared with the control group. Also, the left ventricular end-diastolic pressure was specifically higher in the female rats in response to free fatty acids-containing CLA mix. Furthermore, an additive effect of the free fatty acids-containing CLA mix was seen in the +dP/dt and -dP/dt of female rats compared with the control group. These results indicate that CLA isomers exert differential effects on heart function and suggest the need for a complete evaluation of the benefits, interactions, and potential side effects of each isomer.
机译：本研究旨在通过体内导管技术评估饲喂不同共轭亚油酸（CLA）异构体（顺式9，反式11（c9，t11））的健康雄性和雌性Sprague-Dawley大鼠的心脏功能和反式10，顺式12（t10，c12））从4到20周龄单独和组合使用（以甘油三酸酯或脂肪酸的比例为50:50）。 CLA异构体混合物的甘油三酸酯形式可降低心率，收缩率（+ dP / dt）和舒张率（-dP / dt），收缩压和舒张压，平均动脉压和左心室收缩压与所有其他饮食组相比，雄性大鼠的脂肪含量更高。相反，响应于甘油三酸酯形式的CLA异构体混合物，对雌性大鼠的心脏功能没有明显影响。单独饲喂t10，c12 CLA异构体的雄性大鼠心率+ dP / dt和左室收缩压较低，雌性大鼠的心率较高，但收缩压+ dP / dt和平均动脉压低于对照组。此外，雌性大鼠对含有游离脂肪酸的CLA混合物的反应，左室舒张末期压力特别高。此外，与对照组相比，在雌性大鼠的+ dP / dt和-dP / dt中观察到了含有游离脂肪酸的CLA混合物的累加作用。这些结果表明，CLA异构体会对心脏功能产生不同的影响，并提示需要全面评估每种异构体的益处，相互作用和潜在副作用。

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