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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Physiological role and regulation of the Na+/H+ exchanger.
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Physiological role and regulation of the Na+/H+ exchanger.

机译：Na + / H +交换剂的生理作用和调节。

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摘要

In mammalian eukaryotic cells, the Na+/H+ exchanger is a family of membrane proteins that regulates ions fluxes across membranes. Plasma membrane isoforms of this protein extrude 1 intracellular proton in exchange for 1 extracellular sodium. The family of Na+/H+ exchangers (NHEs) consists of 9 known isoforms, NHE1-NHE9. The NHE1 isoform was the first discovered, is the best characterized, and exists on the plasma membrane of all mammalian cells. It contains an N-terminal 500 amino acid membrane domain that transports ions, plus a 315 amino acid C-terminal, the intracellular regulatory domain. The Na+/H+ exchanger is regulated by both post-translational modifications including protein kinase-mediated phosphorylation, plus by a number of regulatory-binding proteins including phosphatidylinositol-4,5-bisphosphate, calcineurin homologous protein, ezrin, radixin and moesin, calmodulin, carbonic anhydrase II, and tescalcin. The Na+/H+ exchanger is involved in a variety of complex physiological and pathological events that include regulation of intracellular pH, cell movement, heart disease, and cancer. This review summarizes recent advances in the understanding of the physiological role and regulation of this protein.
机译：在哺乳动物的真核细胞中，Na + / H +交换子是一类膜蛋白，可调节跨膜的离子通量。该蛋白的质膜同工型挤出1个胞内质子，以换取1个胞外钠。 Na + / H +交换子（NHE）家族由9种已知的异构体NHE1-NHE9组成。 NHE1同工型是第一个被发现，特征最明确的同种型，并且存在于所有哺乳动物细胞的质膜上。它包含一个N末端的500个氨基酸的离子膜结构域，可运输离子，以及一个315个氨基酸的C末端的细胞内调节结构域。 Na + / H +交换剂受翻译后修饰（包括蛋白激酶介导的磷酸化）和多种调节结合蛋白（包括磷脂酰肌醇-4,5-双磷酸酯，钙调神经磷酸酶同源蛋白，ezrin，辐射素和肌球蛋白，钙调蛋白，碳酸酐酶II和tescalcin。 Na + / H +交换子参与各种复杂的生理和病理事件，包括调节细胞内pH，细胞运动，心脏病和癌症。这篇综述总结了对这种蛋白质的生理作用和调节的理解方面的最新进展。

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