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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Dual X-ray absorptiometry model for characterizing water in the human forearm using multiple frequency bioimpedance analysis.
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Dual X-ray absorptiometry model for characterizing water in the human forearm using multiple frequency bioimpedance analysis.

机译：双X射线吸收法模型，用于使用多频率生物阻抗分析来表征人前臂中的水分。

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摘要

The purpose of this study was to develop a method for measuring intracellular (ICW) and extracellular water (ECW) in the human forearm using multiple frequency bioimpedance analysis (MFBIA). The approach was (i) to measure whole-body and forearm fat-free mass using dual X-ray absorptiometry (DXA); (ii) to use these measurements to estimate the fat-free mass (FFM) resistivity in both the forearm and in the whole body; and (iii) to use the ratio of these FFM resistivities to estimate the resistivity in the ICW and ECW compartments of the forearm. To first demonstrate the accuracy of the DXA software in differentiating lean body mass from fat and bone within a volume of tissue, ex-vivo bovine muscle tissue samples (n = 3) were used to approximate the physical properties of the human forearm. It was found that although the human whole-body software overestimates FFM, it was slightly underestimated by the small animal software. Using this technique, DXA measures of FFM were obtained from human volunteers (n= 11; age = 20 +/- 5 years; height = 170 +/- 12 cm; mass = 64 +/- 16 kg). These measures were used in conjunction with MFBIA measures of impedance of the whole body and of the forearm to determine the resistivities of the ICW and ECW compartments of the forearm, namely 375.8 +/- 25.2 ohms cm and 55.6 +/- 3.7 ohms cm, respectively. These were used in MFBIA equations to calculate the ICW, ECW, and total arm water (TAW) volumes of the human forearm. The calculated TAW and the ECW (+/- SD) volume fraction (667.29 +/- 200.15 mL and 0.169 +/- 0.039 mL, respectively) were in agreement with literature values. MFBIA results were compared with those obtained using nuclear magnetic resonance relaxometry (NMRR). MFBIA was performed on 15 subjects before and after an intense maximal handgrip exercise to estimate changes in water volume in muscle. Following exercise, the total and intracellular water of the forearm increased on average by 8% +/- 3% and 10% +/- 4% (mean +/- SD), respectively. In 5 healthy volunteers, MFBIA and NMRR were performed before and after a similar exercise of the forearm muscle. The changes with exercise of intracellular and total arm water volumes as measured by MFBIA were estimated. The percent increases in total water were found to be 9.4% +/- 4.2% and 9.4% +/- 2.6% and in intracellular water were found to be 10.6% +/- 4.6% and 12.0% +/- 2.8% (mean +/- SD) for NMRR and MFBIA, respectively. The results show that the exercise-induced changes in ICW and TAW determined with the MFBIA model are consistent with those observed with NMRR and radiotracer literature.
机译：这项研究的目的是开发一种使用多频生物阻抗分析（MFBIA）测量人前臂中细胞内（ICW）和细胞外水（ECW）的方法。该方法是（i）使用双X射线吸收法（DXA）测量全身和前臂的无脂肪量; （ii）使用这些测量值来估计前臂和整个身体的无脂肪质量（FFM）电阻率; （iii）使用这些FFM电阻率的比率来估算前臂ICW和ECW隔室中的电阻率。为了首先展示DXA软件在区分一定体积组织中脂肪和骨骼的瘦体重方面的准确性，我们使用离体牛肌肉组织样本（n = 3）来近似人类前臂的物理特性。结果发现，尽管人体全身软件高估了FFM，但小动物软件却低估了它。使用该技术，从人类志愿者中获得了FFA的DXA测量值（n = 11;年龄= 20 +/- 5岁;身高= 170 +/- 12 cm;质量= 64 +/- 16 kg）。这些措施与MFBIA全身和前臂的阻抗措施一起使用，以确定前臂的ICW和ECW隔室的电阻率，即375.8 +/- 25.2 ohms cm和55.6 +/- 3.7 ohms cm，分别。在MFBIA方程中使用这些公式来计算前臂的ICW，ECW和总手臂水量（TAW）。计算的TAW和ECW（+/- SD）体积分数（分别为667.29 +/- 200.15 mL和0.169 +/- 0.039 mL）与文献值一致。将MFBIA结果与使用核磁共振弛豫法（NMRR）获得的结果进行比较。在剧烈的最大握力运动前后，对15位受试者进行了MFBIA，以估计肌肉中水量的变化。运动后，前臂的总水和细胞内水平均分别增加8％+/- 3％和10％+/- 4％（平均+/- SD）。在5名健康志愿者中，在前臂肌肉进行类似锻炼之前和之后进行了MFBIA和NMRR。通过MFBIA测量，估计了运动后细胞内和总手臂水量的变化。发现总水的增加百分比为9.4％+/- 4.2％和9.4％+/- 2.6％，并且发现细胞内水的百分比为10.6％+/- 4.6％和12.0％+/- 2.8％（平均值分别为NMRR和MFBIA。结果表明，MFBIA模型确定的运动引起的ICW和TAW变化与NMRR和放射性示踪剂文献观察到的一致。

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