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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Endothelium-dependent vascular relaxation induced by Globularia alypum extract is mediated by EDHF in perfused rat mesenteric arterial bed
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Endothelium-dependent vascular relaxation induced by Globularia alypum extract is mediated by EDHF in perfused rat mesenteric arterial bed

机译：EDGL介导球根提取物诱导的内皮依赖性血管舒张

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摘要

The vasodilatory effect of Globularia alypum L. (GA) extract was evaluated in rat mesenteric arterial bed precontracted by continuous infusion of phenylephrine (2-4 ng/mL). Bolus injections of GA elicited dose-response vasodilation, which was abolished after endothelium removal. Addition of a nitric oxide synthase inhibitor, N G-nitro-L-arginine methyl ester (100 μmol/L), alone or in the presence of a cyclooxygenase inhibitor, indomethacin (10 μmol/L), did not significantly affect the vasodilation of the mesenteric arterial bed in response to GA extract. These results suggest that GA-induced vasodilation is endothelium dependent but nitric oxide and prostacyclin independent. In the presence of high K + (60 mmol/L), the GA vasodilatory effect was completely abolished, suggesting that the vasodilation effect is mediated by hyperpolarization of the vascular cells. Also, pre-treatment with atropine (a muscarinic receptors antagonist) antagonized the GA-induced vasodilation, suggesting that the vasodilatory effect is mainly mediated by the endothelium-derived hyperpolarizing factor through activation of endothelial muscarinic receptors.
机译：在连续输注去氧肾上腺素（2-4 ng / mL）预收缩的大鼠肠系膜动脉床中评估了球根提取物的血管舒张作用。注射GA的小剂量可引起剂量反应性血管舒张，该作用在去除内皮后被取消。单独或在环氧合酶抑制剂吲哚美辛（10μmol/ L）存在下添加一氧化氮合酶抑制剂N G-硝基-L-精氨酸甲酯（100μmol/ L）不会显着影响药物的血管舒张对GA提取物的肠系膜动脉床。这些结果表明，GA诱导的血管舒张作用是内皮依赖性的，而一氧化氮和前列环素的依赖性是不依赖性的。在高K +（60 mmol / L）存在的情况下，GA的血管舒张作用被完全消除，这表明血管舒张作用是由血管细胞的超极化介导的。同样，用阿托品（毒蕈碱受体拮抗剂）预处理拮抗GA诱导的血管舒张作用，这表明血管舒张作用主要是通过内皮毒蕈碱受体的活化而由内皮衍生的超极化因子介导的。

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