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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Radioprotective effect of curcuma longa extract on γ-irradiation-induced oxidative stress in rats
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Radioprotective effect of curcuma longa extract on γ-irradiation-induced oxidative stress in rats

机译：姜黄提取物对γ射线诱导的大鼠氧化应激的辐射防护作用

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摘要

This study was conducted to evaluate the modulatory effect of aqueous extract of Curcuma longa (L.) against girradiation (GR), which induces biochemical disorders in male rats. The sublethal dose of GR was determined in primary hepatocytes. Also, the effect of C. longa extract was examined for its activity against GR. In rats, C. longa extract was administered daily (200 mg/kg body mass) for 21 days before, and 7 days after GR exposure (6.5 Gy). The lipid profile and antioxidant status, as well as levels of transaminases, interleukin-6 (IL-6), and tumour necrosis factor a (TNFα) were assessed. The results showed that in hepatocytes, the aqueous extract exhibited radioprotective activity against exposure to GR. Exposure of untreated rats to GR resulted in transaminase disorders, lipid abnormalitie, elevation of lipid peroxidation, trace element alterations, release of IL-6 and TNF, and decrease in glutathione and protein level of superoxide dismutase-1 (SOD-1) and peroxiredoxin-1 (PRDX-1). However, treatment of rats with this extract before and after GR exposure improved antioxidant status and minimized the radiation-induced increase in inflammatory cytokines. Changes occurred in the tissue levels of trace elements, and the protein levels of SOD-1 and PRDX-1 were also modulated by C. longa extract. Overall, C. longa exerted a beneficial radioprotective effect against radiation-induced oxidative stress in male rats by alleviating pathological disorders and modulating antioxidant enzymes.
机译：进行这项研究以评估姜黄（L.）的水提物对辐照（GR）的调节作用，辐照会诱发雄性大鼠的生化异常。在原代肝细胞中确定GR的亚致死剂量。另外，检查了长枝梭菌提取物对GR的活性。在大鼠中，每天（200 mg / kg体重）服用长双歧杆菌提取物，持续暴露于GR（6.5 Gy）之前21天和之后7天。评估了脂质分布和抗氧化剂状态，以及转氨酶，白介素6（IL-6）和肿瘤坏死因子a（TNFα）的水平。结果表明，在肝细胞中，水提取物对暴露于GR具有辐射防护活性。未经处理的大鼠暴露于GR会导致转氨酶异常，脂质异常，脂质过氧化升高，微量元素改变，IL-6和TNF释放以及谷胱甘肽和超氧化物歧化酶-1（SOD-1）和过氧化物酶的蛋白质水平降低-1（PRDX-1）。但是，在GR暴露之前和之后，用这种提取物治疗大鼠，可以改善抗氧化剂的状态，并最大程度地减少辐射诱导的炎症性细胞因子的增加。组织中微量元素的含量发生了变化，C。longa提取物也调节了SOD-1和PRDX-1的蛋白含量。总体而言，龙眼衣原体通过减轻病理性疾病和调节抗氧化酶，对雄性大鼠辐射诱导的氧化应激产生了有益的辐射防护作用。

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