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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >The effect of endogenous estrogen on dopplerestimated right ventricular systolic pressure during exercise
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The effect of endogenous estrogen on dopplerestimated right ventricular systolic pressure during exercise

机译：内源性雌激素对运动过程中多普勒估计的右心室收缩压的影响

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摘要

We evaluated the effect of endogenous estrogen levels on exercise-related changes in right ventricular systolic pressure (RVSP) of healthy, eumenorrheic, sedentary women. Volunteers were studied at two separates phases of the menstrual cycle (LO and HI estrogen phases), exercised on a semi-supine ergometer with escalating workload and monitored continuously by 12-lead ECG and automated blood pressure cuff. At each exercise stage, Doppler echocardiography measurements were obtained and analyzed to determine RVSP. Fourteen subjects (age 24 ± 5) were studied. Exercise duration was significantly higher on the HI estrogen day, but no significant differences in hemodynamic response to exercise were found between the two study days. There were also no significant differences with respect to heart rate (HR) acceleration during early exercise, as well as resting and peak RVSP, HR, blood pressure, and rate pressure product. Doppler-estimated RVSP demonstrated a linear relationship to HR at a ratio of 1 mm Hg (1 mm Hg = 133.3224 Pa) for every 5 bpm (beats per minute) increase in HR. There were no differences in the slope of this relationship between HI and LO estrogen phases of the menstrual cycle. Our findings did not demonstrate any effect of endogenous estrogen levels on the modulation of the pulmonary vascular response to exercise in healthy women.
机译：我们评估了内源性雌激素水平对健康的，非漏尿的，久坐的女性右室收缩压（RVSP）与运动有关的变化的影响。在月经周期的两个不同阶段（LO和HI雌激素阶段）对志愿者进行研究，在半仰卧起坐测力计上进行锻炼，并增加工作量，并通过12导联心电图和自动血压袖带进行连续监测。在每个运动阶段，获取多普勒超声心动图测量值并进行分析以确定RVSP。研究了十四名受试者（24±5岁）。在HI雌激素日，运动时间明显更长，但是在两个研究日之间，运动对血液动力学的反应没有发现显着差异。早期运动期间的心率（HR）加速以及静息和峰值RVSP，HR，血压和心率压积之间也没有显着差异。多普勒估计的RVSP与HR呈线性关系，每增加5 bpm（每分钟心跳数），心率便以1 mm Hg（1 mm Hg = 133.3224 Pa）的比率变化。月经周期的HI和LO雌激素阶段之间这种关系的斜率没有差异。我们的发现并未证明内源性雌激素水平对健康女性运动对肺血管反应调节的影响。

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