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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Plasma and cerebrospinal fluid concentration of neuropeptide Y, serotonin, and catecholamines in patients under propofol or isoflurane anesthesia.
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Plasma and cerebrospinal fluid concentration of neuropeptide Y, serotonin, and catecholamines in patients under propofol or isoflurane anesthesia.

机译：丙泊酚或异氟烷麻醉下患者的神经肽Y，血清素和儿茶酚胺的血浆和脑脊液浓度

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摘要

Propofol is a widely used anesthetic for both induction and maintenance of anesthesia during surgery. A strong feeling of hunger has been reported during the early recovery period after propofol anesthesia. We have investigated the effect of propofol on appetite in 10 patients undergoing a craniotomy and in parallel measured neuropeptide Y (NPY), catecholamines, and serotonin levels in the cerebrospinal fluid and plasma during anesthesia. Ten patients anesthetized with a volatile agent (isoflurane) served as a control group. Plasma NPY and catecholamines levels were not affected by surgery at any time. We observed a strong increase in NPY concentrations in the cerebrospinal fluid independently of the anesthetic technique agent used, whereas catecholamines were unchanged. We found that serotonin concentrations decreased significantly in the plasma (but not in the cerebrospinal fluid) of patients treated by propofol when compared with the control group; this decrease was associated with an increase of hunger early postoperatively. We concluded that the proappetite effect of propofol is mediated through a decrease of serotonin at the peripheral level.
机译：异丙酚是在手术过程中诱导和维持麻醉的广泛使用的麻醉剂。据报道，在异丙酚麻醉后的早期恢复期间，强烈的饥饿感。我们已经研究了10例接受开颅手术并在麻醉过程中同时测量脑脊液和血浆中神经肽Y（NPY），儿茶酚胺和血清素水平的丙泊酚对食欲的影响。十例用挥发性药物（异氟醚）麻醉的患者作为对照组。血浆NPY和儿茶酚胺水平在任何时候均不受手术影响。我们观察到，与所使用的麻醉剂无关，脑脊液中NPY浓度显着增加，而儿茶酚胺未改变。我们发现，与对照组相比，丙泊酚治疗的患者血浆（而非脑脊液）中血清素浓度显着降低;这种减少与术后早期饥饿的增加有关。我们得出的结论是，丙泊酚的食欲作用是通过在外周水平降低5-羟色胺介导的。

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