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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >The negative inotropic action of catecholamines: role of beta3-adrenoceptors.
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The negative inotropic action of catecholamines: role of beta3-adrenoceptors.

机译：儿茶酚胺的负性肌力作用：β3-肾上腺素受体的作用。

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摘要

There is now evidence for the involvement of four beta-adrenoceptor populations in the regulation of cardiac function by catecholamines. Beta1- and beta2-adrenoceptor stimulation classically produces an increase in contractility. A fourth beta-adrenoceptor, as yet uncloned and designated provisionally as a beta4-adrenoceptor, also mediates a positive inotropic effect. Beta3-adrenoceptors, which had been cloned at the end of the eighties, has been extensively studied as a potential target for antiobesity and antidiabetic drugs. Its characterization in the heart has opened new fields of investigations for the understanding of the cardiac adrenergic regulation. This review describes the cardiac electrical and mechanical effects induced by Beta3-adrenoceptor stimulation in different species (including human), as well as the signaling pathway. It also analyzes the role of these receptors in the abnormal responsiveness of catecholamines in heart failure.
机译：现在有证据表明儿茶酚胺参与了四个β-肾上腺素能受体群对心脏功能的调节。 Beta 1和beta 2肾上腺素受体刺激经典地产生收缩力的增加。第四种β-肾上腺素受体，尚未被克隆并暂时指定为β4-肾上腺素受体，也介导正性肌力作用。在八十年代末被克隆的β3-肾上腺素受体已经被广泛研究作为抗肥胖和抗糖尿病药物的潜在靶标。其在心脏中的表征为了解心脏肾上腺素调节开辟了新的研究领域。这篇综述描述了在不同物种（包括人类）中，β3-肾上腺素受体刺激引起的心脏电和机械作用，以及信号传导途径。它还分析了这些受体在心力衰竭中儿茶酚胺异常反应中的作用。

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