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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Acute plasma volume expansion alters cardiovascular but not thermal function during moderate intensity prolonged exercise.
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Acute plasma volume expansion alters cardiovascular but not thermal function during moderate intensity prolonged exercise.

机译：在中等强度的长时间运动中，急性血浆体积扩张会改变心血管功能，但不会改变热功能。

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摘要

To investigate the hypothesis that the increase in plasma volume (PV) that typically occurs with training results in improved cardiovascular and thermal regulation during prolonged exercise, eight untrained males (V(O2)peak = 3.52 +/- 0.12 L x min(-1)) performed 90 min of cycle ergometry at 62% V(O2)peak before and after acute PV expansion. Subjects were infused with a PV-expanding solution (dextran (6%) or Pentaspan (10%)) equivalent to 6.7 mL x kg(-1) body mass (PVX) or acted as their own control (CON) in a randomized order. PVX resulted in a calculated 15.8% increase in resting PV, which relative to CON, was maintained throughout the exercise (P < 0.05). During PVX, heart rate was lower (P < 0.05) and stroke volume and cardiac output were higher (P < 0.05) during the exercise. Mean arterial pressure and total peripheral resistance, although altered by exercise (P < 0.05), were not different between the two conditions. Core temperature, which was progressively increased by the exercise (P < 0.01), was not affected by PVX. A similar decrease in body weight was observed between the conditions as a result of the exercise (P < 0.01). These results indicate that acute PVX alters cardiovascular performance without affecting the thermoregulatory response to prolonged cycle exercise.
机译：为了研究假说，长期训练中血浆量（PV）的增加通常会导致长时间运动中心血管和热调节的改善，八名未经训练的男性（V（O2）peak = 3.52 +/- 0.12 L x min（-1 ））在急性PV扩张前后，在62％V（O2）峰值下执行90分钟的循环测功。向受试者灌输相当于6.7 mL x kg（-1）体重（PVX）的PV扩展溶液（右旋糖酐（6％）或Pentaspan（10％）），或以随机顺序作为自己的对照（CON） 。 PVX导致静息PV的计算增加了15.8％，相对于CON，在整个运动过程中均保持不变（P <0.05）。在PVX期间，运动期间心率较低（P <0.05），中风量和心输出量较高（P <0.05）。平均动脉压和总外周阻力尽管因运动而改变（P <0.05），但在两种情况下没有差异。运动引起的核心温度逐渐升高（P <0.01），不受PVX影响。在运动之间，运动后的体重也有类似的下降（P <0.01）。这些结果表明，急性PVX可以改变心血管功能，而不会影响对延长周期运动的体温调节反应。

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