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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Pancreatic secretory response to feeding in the calf: CCK-A receptors, but not CCK-B/gastrin receptors are involved.
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Pancreatic secretory response to feeding in the calf: CCK-A receptors, but not CCK-B/gastrin receptors are involved.

机译：饲喂小牛的胰腺分泌反应：涉及CCK-A受体，但不涉及CCK-B /胃泌素受体。

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摘要

In bovine species, as in human, the pancreas predominantly expresses cholecystokinin-B (CCK-B)/gastrin receptors. However, the role of this receptor in the regulation of meal-stimulated pancreatic enzyme release has not been determined. In milk-fed calves, we previously described prandial patterns of exocrine pancreatic secretion and a long prefeeding phase was observed. The present study was aimed at determining both the role of external stimuli in the outset of the prefeeding phase and the implication of pancreatic CCK-A and CCK-B/gastrin receptors in the mediation of pancreatic response to feeding. The first objective was studied by suppressing external stimuli associated with food intake (unexpected meal) and the second by infusing highly specific and potent antagonists of CCK-A (SR 27897) and CCK-B/gastrin (PD 135158) receptors during the prandial period. When calves were given an unexpected meal, the long prefeeding increase in pancreatic secretion was absent. SR 27897 (but not PD 135158) inhibited the preprandial phase and greatly reduced postprandial pancreatic juice and enzyme outflows. The expectancy of a meal seemed to elicit an increased pancreatic response right before a meal and CCK-A receptors may mediate this information via neural pathways. The implication of CCK and CCK-A receptors in mediating the postfeeding pancreatic response was also demonstrated. The participation of CCK-B/gastrin receptors in this regulation was not demonstrated.
机译：像人类一样，在牛中，胰腺主要表达胆囊收缩素-B（CCK-B）/胃泌素受体。然而，尚未确定该受体在调节膳食刺激的胰腺酶释放中的作用。在奶牛犊中，我们先前描述了外分泌胰腺分泌的饮食模式，并观察到较长的预喂养期。本研究旨在确定外部刺激在预喂养阶段开始时的作用以及胰腺CCK-A和CCK-B /胃泌素受体在胰腺对喂养反应的介导中的作用。第一个目标是通过抑制与进食相关的外部刺激（意外进餐）来研究的，第二个目标是在餐期间注入CCK-A（SR 27897）和CCK-B /胃泌素（PD 135158）受体的高特异性强效拮抗剂。当给小牛吃一顿意外的饭时，就没有长期预喂养胰腺分泌增加的情况。 SR 27897（但不是PD 135158）抑制了餐前阶段，并大大减少了餐后胰液和酶的流出。饭前的期望似乎引起饭前胰腺反应的增强，CCK-A受体可能通过神经途径介导该信息。还证明了CCK和CCK-A受体在介导喂养后胰腺反应中的意义。没有证明CCK-B /胃泌素受体参与该调节。

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